ACETOHYDROXAMIC ACID

PRODUCT IDENTIFICATION

CAS NO. 546-88-3

ACETOHYDROXAMIC ACID

EINECS NO. 208-913-8
FORMULA CH3CONHOH
MOL WT. 75.07

H.S. CODE

 

TOXICITY

 
SYNONYMS AHA; Lithostat; Methylhydroxamic acid; N-Acetylhydroxylamine;
Acethydroxamsaeure; Acetic acid, oxime; Acetohydroximic acid; Acetylhydroxamic acid; Acide acetohydroxamique; Acido acetohidroxamico; Acidum acetohydroxamicum; N-Acetylhydroxylamine; N-Hydroxyacetamide;
DERIVATION

 

CLASSIFICATION

CHELATING AGENTS / HYDROXAMIC ACIDS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 86 - 91 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Hydroxamic acid is an organic compound that contains the group -C(=O)NHOH; an amine is is inserted into an carboxylic acid. This structure is useful for a variety of roles in biology and medicine. This compound can be formed by Angeli-Rimini reaction between an aldehyde and sulfinic acid or N-hydroxysulfonamide. Hydroxamic acid structure provides a variety of roles in biology and medicine (chelation therapy), It inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths. Marimastat is a hydroxamic acid active as an Antineoplastic by inhibiting a matrix metalloproteinase. The most characteristic property of hydroxamic acid is the metal binding (chelators). Sideromycins are hydroxamic acid compounds active as antibiotic. Siderophores are hydroxamic acid compounds produced by microorganisms for the abstraction of iron ions and dissolve these ions as soluble Fe ion complexes for active transport mechanism. Deferoxamine isolated from Streptomyces pilosus is a chelating agent used as an antidote to iron poisoning. Hydroxamic acid compounds are used as extractants for the separation of valuable metals or minerals including copper, lead, gold, other rare earth metals and kaolin. Hydroxamic acids are used to produce corresponding isocyanates by dehydration followed by rearrangement reaction.
SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

98.0% min

MELTING POINT

86 - 91 C

LOSS ON DRYING

1.0% min

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 61, Safety Phrases: 53-45