| CAS
NO. |
73218-79-8;
87913-86-8 |
|
| EINECS
NO. |
|
| FORMULA |
C9H10Cl2N4O·HCl |
| MOL
WT. |
281.57 |
|
H.S.
CODE
|
|
| TOXICITY |
Orat
rat LD50: 38mg/kg
|
| SYNONYMS |
3,5-Dichloro-4-(2-imidazolidinylidenimino)aniline hydrochloride;
|
|
p-Aminoclonidine hydrochloride;
Iopidine; Iopidine ophthalmic; 2,6-Dichloro-N(1)-(2-imidazolidinylidene)-1,4-benzenediamine
hydrochloride; 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine hydrochloride;
2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine monohydrochloride;
2,6-Dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine
hydrochloride; |
|
DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to
off-white
crystalline powder |
| MELTING
POINT |
|
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
|
|
SOLVENT
SOLUBILITY
|
|
| pH |
|
| VAPOR
DENSITY |
|
| AUTOIGNITION |
|
| NFPA
RATINGS |
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
| Imidazolidine is
the hydrogen-saturated analogue of imidazole and
imidazoline dihydrogenated one. Imidazoline has a single double bond but
imidazolidine has no double bond. The resonance structures of imidazole keep the
aromaticity intact. Imidazole is a base and an excellent nucleophile. It reacts
at the NH nitrogen. Generaly nucleophilic substitutions at the carbon atoms
except C-2 are difficult with imidazole. But It is susceptible to electrophilic
attacks at the carbon atoms with imidazoline and imidazolidine.
Imidazoline molecules are sympathomimetic agents
effecting on alpha-adrenergic receptors primarily
and little effecting on beta-adrenergic
receptors. The imidazoline
derivatives of adrenergic alpha-agonist include oxymetazoline
(CAS RN: 1491-59-4) , xylometazoline
(CAS RN: 526-36-3), tetrahydrozoline
(CAS RN: 84-22-0) , and naphazoline
(CAS RN: 835-31-4), They are found in
topical ophthalmic and nasal decongestants.
Apraclonidine
(p-amino substituted clonidine) is an adrenergic agonist that acts
predominantly at alpha adrenergic receptors; used to treat and prevent ocular
hypertension. It reduces
intraocular pressure in the treatment of open-angle
glaucoma.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
to -off-white crystalline powder |
|
IDENTIFICATION |
Conforms
Test A, B
|
|
ASSAY
|
98.0
- 101.0%
|
|
LOSS ON DRYING |
1.0%
max
|
|
PH
|
5.0
- 6.6
|
|
RESIDUE ON IGNITION |
0.1%
max
|
|
INDIVIDUAL
IMPURITY
|
I1.0%
max
|
|
TOTAL
IMPURITY
|
2.0%
max
|
|
HEAVY
METALS
|
20ppm
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
6.1
(Packing Group: I) |
| UN
NO. |
2811 |
| OTHER
INFORMATION |
|
Hazard Symbols: T, Risk Phrases: 23/24/25,
Safety
Phrases: 22-36/37/39-45 |
|
PRICE INFORMATION |
|
|
