BAICALEIN

Synonyms. Baicalein; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one; 5,6,7-Trihydroxyflavone; 5,6,7-trihydroxy-2-phenyl-chromen-4-one; 5,6,7-trihydroxy-2-phenylchromen-4-one; Noroxylin; Noroxylin; 5,7-Trihydroxyflavone;

BAICALEIN

 

PRODUCT IDENTIFICATION

CAS RN

491-67-8

EINECS RN

 

FORMULA

 C15H10O5

MOLE WEIGHT

270.24

H.S CODE

 2933.99.7900

SMILES

 c1(cc(c2c(o1)cc(c(c2O)O)O)=O)c1ccccc1

CLASSIFICATION

Flavone, Antioxidant, Hormone antagonist, Prostaglandin antagonist

EXTRA NOTES

 A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.(ChEBI)

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to pale-yellow solid

MELTING POINT

264 - 265 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Insoluble

SOLVENT SOLUBILITY Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid. Sparingly soluble in Chloroform

VAPOR DENSITY

 

log P(octanol-water)

 3.27

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents, Strong bases, moisture

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Baicalein

Google Scholar Search - Baicalein

Drug Information Portal (U.S. National Library of Medicine) - Baicalein

PubChem Compound Summary - Baicalein

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Baicalein

http://www.ebi.ac.uk/ - Baicalein

http://www.ncbi.nlm.nih.gov/ - Baicalein

http://ci.nii.ac.jp/
The active ingredients of ‘golden root’ of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p 0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities.

 

SALES SPECIFICATION

APPEARANCE

white to pale-yellow solid

CONTENT

98% min (HPLC)

PARTICLE SIZE

80 mesh (100%)
RESIDUE ON IGNITION

1.0% max

RESIDUAL SOLVENTS

EU2000

HEAVY METALS

20ppm max

ARSENIC

2ppm max

LOSS ON DRYING

3.0% max
MICROBIOLOGY

Aerobic Plate Count: 100 organisms/g max
E. coli,: negative
Salmonella: negative
Staphylococcusaureus: negative
Aspergllus species: negative
Listeria: negative
Pseudomonas: negative
Total Mold/Yeast: 100 cfu/g max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

GHS

  

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-P335

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

Xi

RISK PHRASES

36/37/38

SAFETY PHRASES

 26-36

 

PACKING

Preserve in light-resistant and well-closed containers