COENZYME Q10

PRODUCT IDENTIFICATION

CAS NO. 303-98-0
13448-14-1
55870-43-4

COENZYME Q10

EINECS NO. 206-147-9
FORMULA C59H90O4
MOL WT. 863.34

H.S. CODE

 

TOXICITY

 
SYNONYMS Ubidecarenone; Ubiquinone 10; Ubiquinone 50;
Udekinon; (all-E)-2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38- tetracontadecaenyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; 2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecae nyl)-5,6- dimethoxy-3-methyl-p-benzoquinone; 2-(3,7,11,15,19,23,27,31,35,39-Dec amethyl- 2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6- dimethoxy- 3-methyl-p- benz oquinone; Ubiquinone 50;  CoQ10 ; Emitolon; Heartcin; Inokiten; Justquinon; Luvacor; Neuquinon; Neuquinone; Ubidecarenona; Ubidecarenone; Ubiquinone Q10;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to orange crystalline powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

Health: 1; Flammability: 0; Reactivity: 0

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Coenzyme Q is a fat soluble quinone terminated compound with a sequence of conjugated isoprene units. The structure is related to carotenoid, vitamin K and vitamin E. It is stable in acid but insoluble in a;kali. The most common coenzyme Q in human mitochondria is coenzyme Q 10 (ubidecarenone) which contains ten isoprene units. The chemical designation is 2-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39- decamethyl- 2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl- 2,5-cyclohexadiene-1,4-dione. It occurs in the lipid core of inner mitochondrion membranes. It is an essential component of the electron transfer chain to ubiquinol-cytochrome-c reductase. Redox (Oxidation-reduction) reactions occur simultaneously and  represent the main source of biological energy. Coenzyme acts as a reduction/oxidation agent or as a similar electron transfer. It acts as an endogenous antioxidant to prevent mitochondrion membranes and DNA. It is called ubiquinone or ubiquinol as it is is readily oxidized to alcohol. Because of its antioxidant property, Coenzyme Q is used as a dietary supplement. Coenzyme antioxidant benefits to the brain is also studied for the treatment of neurodegenerative disease.

Coenzyme is a nonprotein organic molecule that that binds with the inactive apoenzyme to form holoenzyme (the active enzyme). Coenzymes frequently contain phosphorylated water-soluble vitamins as part of their structure. Non-vitamin coenzymes include heme coenzymes in catalytic hemoproteins. The prosthetic group (nonprotein portion of the enzyme) functions as an acceptor of electrons or functional groupings. The apoenzyme can function singly. Certain enzymes need metal (copper, manganese, and magnesium) ions for the activation. Groups of coenzyme include:

  • Adenosine triphosphate
  • Biopterin
  • Biotin
  • Cobalamins
  • Coenzyme PQQ (Pyrroloquinoline Quinone)
  • Flavins
  • Glutathione
  • Heme
  • Lipoic acids
  • NAD (Nicotinamide adenine dinucleotide)
  • NADP (Nicotinamide adenine dinucleotide phosphate)
  • Nicotinamide nucleotides
  • Pyridoxal Phosphate
  • Sphingolipid Activator Proteins
  • Tetrahydrofolates
  • Thiamine Pyrophosphate
  • Ubiquinones
SALES SPECIFICATION

APPEARANCE

yellow to orange crystalline powder

IDENTIFICATION

Passes tests

ASSAY

98.0 - 102.0%

WATER

0.2% max

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

10ppm max

ARSENIC

2ppm max

ISOMER IMPURITY

0.5% max

TOTAL IMPURITY

1.0% max

INDIVIDUAL IMPURITY

0.5% max

TOTAL PLATE COUNT 1,000/g max
YEAST AND MOLD 100/g max
E.COLI negative
SALMONELLA negative
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: 22, Safety Phrases: 22-24/25