COLISTIN SULFATE
COLISTIN SULFATE
N-((1S)-3-amino-1-(((1S,2R)-1-(((1S)-3-amino-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)- 12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19- heptazacyclotricos-21-yl)carbamoyl)propyl) carbamoyl)-2-hydroxy-propyl) carbamoyl)propyl)-6-methyl-octanamide sulfuric acid; Belcomycin; Colimycin sulfate; Colistins sulfate; Coly-Mycin S; Polymyxin E sulfate;

CAS RN

:

  

1264-72-8

EINECS RN

:

  

216-911-3

FORMULA

:

  

C53H102N16O17S

MASS

:

  

1267.54

DESCRIPTION

:

  

Colistin is a polymyxin class antibiotic which has the general structure of cyclic peptide with a long hydrophobic tail. They are cationic detergent antibiotics which interfere the structure of the bacterial cell membrane and cause neuromuscular and kidney damage by acting of phospholipids. At least eleven different members of the polymyxin group have been identified and they are designated by a suffix letter. They demonstrate specific activity against gram-negative bacteria such as Proteus vulgaris, Escherichia coli, Hemophilus influenzae, Aerobacter aerogenes, Klebsiella pneumoniae and especially Pseudomonas aeruginosa. Colistin is composed of Polymyxins E1 and E2 (or Colistins A, B, and C). Colistin is is the least toxic member of the group. Colistin is used as a sulfate or as sulfomethylated form; administered orally, parenterally, and topically.

SPECIFICATION:

Appearance

white to off-white powder

Identification

Conforms

Potency (Dried basis)

19000µ/mg

pH

4.0 - 6.0

Residue on ignition

1.0% max

Loss on drying

3.5% max

Optical rotation

-63° ~ -73°

Arsenic salt

2ppm max

Heavy metals

20ppm max

Sulfate

16.0 - 18.0%

Particle size

300mesh (98% min)


POLYMYXIN DERIVATIVES:

 

Product

CAS RN

Colistin 1066-17-7
Colistin sulfate 1264-72-8
polypeptin 1404-32-6
Polymyxin D 1404-29-1
Polymyxin A 1404-24-6
Polymyxin B 1404-26-8
Bacitracin1 1405-87-4
Bacitracin zinc 1405-89-6
Polymyxin B Sulfate1 1405-20-5
Sulfomyxin1 1405-52-3
Polymyxin methane sulfonate 1406-68-4
Polymyxin 1406-11-7
Polymyxin B-methanesulfonic acid 1407-09-6
Polymyxin B1 4135-11-9
Polymyxin E1, 7-L-theonine- 6683-17-6
Colistin A 7722-44-3
Cortisporin 8024-64-4
Neosporin 8057-37-2
Colistimethate sodium 8068-28-8
Subtilisin 9014-01-1
Polymyxin D1 10072-50-1
Colistinmethanesulfonic acid 12705-41-8

Colistin sodium methanesulfonate

21362-08-3

Colistin nonapeptide 32530-94-2
Neomycin-polymyxin mixture 51273-62-2

Isododeacnoyl colistin nonapeptide hydrochloride

51868-12-3

Isononanoyl colistin nonapeptide hydrochloride

51868-13-4
Isoheptanoyl colistin nonapeptide hydrochloride 51868-14-5
alpha-N-n-Nonanoyl colistin nonapeptide hydrochloride 51887-93-5

n-Hexanoyl colistin nonapeptide hydrochloride

51887-95-7

alpha-N-n-Decanoyl colistin nonapeptide hydrochloride

51887-94-6
alpha-N-n-Tetradecanoyl colistin nonapeptide hydrochloride 51887-92-4

alpha-N-n-Dodecanoyl colistin nonapeptide hydrochloride

51887-91-3
alpha-N-n-Undecanoyl colistin nonapeptide hydrochloride 51887-90-2

alpha-N-Octanoyl colistin nonapeptide hydrochloride

51921-46-1
Colistin hydrochloride 52051-38-4
Mix(cortisporin, mixt. with neomycin sulfate, polymyxin B sulfate ) 52218-57-2
Phenoxyacetyl colistin nonapeptide hydrochloride 52396-34-6
Colistin nonapeptide hydrochloridee 52396-32-4

2-Phenylbutyryl colistin nonapeptide hydrochloride

52438-36-5

beta-Naphthalenecarbonyl colistin nonapeptide hydrochloride

52438-37-6
Mix(polymyxin B, trimethoprim) 53320-96-0
Colimecycline 58298-92-3
Corti-biciron 62253-16-1
Polymyxin S1 63700-38-9
Polymyxin T1 63700-39-0
Polymyxin A sulfate 63885-04-1
Polymyxin F hydrochloride 64684-15-7
Polymyxin F1 67880-66-4
Colistin heptapeptide 75748-25-3
Deacylpolymyxin B 76014-40-9
Pelargonoyl-cyclic decapeptide polymyxin B1 76721-93-2
Polymagma C 77554-83-7
Pelargonoyl cyclic decapeptide polymyxin M1 77554-83-7
Polymagma 78393-44-9
Pulpomixine 78515-94-3
Maxitrol 78666-15-6
Mix(neomycin, nystatin, polymyxin B sulfate, acetarsol, dimethicone) 78891-94-8
Polymyxin B nonapeptide 86408-36-8
Mix(bacitracin, polymyxin B) 95918-76-6
Mix(polymyxin B neomycin, fludrocortisone acetate, lidocaine, benzalkonium chloride) 99401-18-0
Polyspectran OS 117733-87-6
Mix(cortisporin, polymyxin B) 118933-13-4
Mix(hydrocortisone, dibucaine, neomycin sulfate, polymyxin sulfate) 123354-95-0
Polymyxin B octapeptide 142563-39-1
Polymyxin B heptapeptide 142563-40-4
Dexapolyspectran 143305-95-7