CYCLEN (1,4,7,10-TETRAAZACYCLODODECANE)

CYCLEN

PRODUCT IDENTIFICATION

CAS NO.

294-90-6

CYCLEN

EINECS NO.

FORMULA

C₈H₂₀N₄

MOL WT.

172.27

H.S. CODE

TOXICITY

SYNONYMS

Cyclen; 1,4,7,10-Tetraazacyclododecane;

SMILES

C1CNCCNCCNCCN1

CLASSIFICATION

Crown ethers

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

off- white to slightly yellow crystalline powder

MELTING POINT

108 - 113 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Cyclen

Wikipedia Linking - Cyclen

Google Scholar Search - Cyclen

U.S. National Library of Medicine - Cyclen

PubChem Compound Summary - Cyclen

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Cyclen

http://www.ebi.ac.uk/chebi/ - Cyclen

http://www.ncbi.nlm.nih.gov/ - Cyclen

Local:
Cyclen (1,4,7,10-tetraazacyclododecane) is the aza analogues of crown ethers with repeating (-CH₂CH₂N) units. Cyclam is 1,4,8,11-Tetraazacyclotetradecane with repeating (-CH₂CH₂CH₂N) units. They are starting materials to produce macrocyclic polyamine metal-complexing agents. They coordinate more than one metal ions in their central cavity. They are used as a ligand in chemistry for the applications of diagnostic imaging technique to identify medical condition or disease and for the development of medication as a therapeutic agent and pharmaceutic aid.

Molecular compounds of Cyclen

Product	CAS RN
Cyclen	294-90-6
1,4,8,11-tetraazacyclotetradecane	295-37-4
1,4,7,10,13-pentaazacyclopentadecane	295-64-7
1,4,7,10-tetraazacyclododecane tetrahydrochloride	10045-25-7
Dihydrotentoxin	54987-63-2
Hexacyclen trisulfate	56187-09-8
Dichloro(1,4,7,10-tetraazacyclododecyl)copper	58081-69-9
1,4,7-triazacyclononane trihydrochloride	58966-93-1
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid	60239-18-1
1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane	71089-74-2
Gadoteric acid	72573-82-1
1,4,7,10-Tetramethyl-1,4,7,10-tetraazacyclododecane	76282-33-2
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)	91987-74-5
Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate	92923-44-9
Dichloro(1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecyl)copper	94955-61-0
1,4,7-Tris((4-methylphenyl)sulfonyl)-10-(methylsulfonyl)-1,4,7,10-tetraazacyclododecane	99892-20-3
Plerixafor(AMD 3100)	110078-46-1
Gadolinium 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane	112188-16-6
N,N',N'',N'''-Tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane	119167-08-7
Gadoteridol	120066-54-8
Gadolinium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetrakis(methylene phosphonic acid)	120721-77-9
Calteridol calcium	121915-83-1
Tri-tert-butyl 1 4 7 10-tetraazacyclododeca	122555-91-3
2-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid	123317-51-1
4-Bromoacetamidobenzyl-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid	126753-62-6
4-Aminophenylethyl-1,4,7,10-tetraazacyclodecane-N,N',N'',N'''-tetraacetic acid	130707-75-4
Tri-tert-butyl 1 4 7 10-tetraazacyclodod	137076-54-1
Gadobutrol	138071-82-6
Dota-glycyl-glycyl-glycyl-(4-nitrophenyl)alanine amide	149206-86-0
Calcobutrol	151878-23-8
1,4,7-tris-Boc-1,4,7,10-tetraaza-cyclododecane	175854-39-4
AMD3465	185991-07-5
Edotreotide	204318-14-9
Gadomelitol	227622-74-4
Yttrium Y90 Tacatuzumab	476413-07-7
Yttrium Y90 Epratuzumab Tetraxetan	501423-25-2
Yttrium Y90 Labetuzumab Tetraxetan	501423-30-9
Gadodenterate	544697-52-1

SALES SPECIFICATION

APPEARANCE

off- white to slightly yellow crystalline powder

ASSAY (G.C)

99.0% min

MELTING POINT

108 - 113 C

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity, Oral. Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Causes severe skin burns and eye damage. Harmful in contact with skin. Harmful if swallowed. Very toxic to aquatic life with long lasting effects

GHS

SIGNAL WORD

Danger

PICTOGRAMS