| CAS
NO. |
58-73-1
147-24-0 (hydrochloride)
88637-37-0 (citrate) |
|
| EINECS
NO. |
200-396-7 |
| FORMULA |
C17H21NO |
| MOL
WT. |
255.36 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
beta-Dimethylaminoethanol
diphenylmethyl ether; |
| 2-(Benzhydryloxy)-N,N-dimethylethylamine;
2-(Diphenylmethoxy)-N,N-dimethylethylamine; N,N-Dimethyl-4,4-diphenyl-3-oxabutylamine; Benzhydramine;
Benzhydroamina; Difenhidramina; 2-(Diphenylmethoxy)-N,N-dimethylethanamine;
N,N-dimethyl-2-(diphenylmethoxy)ethylamine; Difenidramina;
Diphenhydraminum; alpha-(2-Dimethylaminoethoxy)diphenylmethane;
beta-Dimethylamino-aethyl-benzhydryl-aether; beta-Dimethylaminoethylbenzhydrylether;
Benzhydraminum; Benzhydril; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
clear
to light yellow liquid |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
1.01 - 1.02 |
| SOLUBILITY
IN WATER |
soluble |
| pH |
|
| VAPOR DENSITY |
|
|
REFRACTIVE
INDEX
|
|
|
NFPA
RATINGS
|
|
|
AUTOIGNITION
|
|
|
FLASH
POINT
|
|
| STABILITY |
Stable under normal conditions. |
|
APPLICATIONS
|
|
Diphenhydramine has the traditional antihistamine structure.
- Diphenyl two aromatic rings
- CO connected to the central carbon
- Short chain alkyl group bridge
between the central carbon and amine
(Ethanolamine connected to the central carbon)
Diphenhydramine is the oldest antihistamine of Histamine H1 antagonist working
by blocking the effect of histamine at H1 receptor sites with antiemetic,
antitussive, anticholinergic and with some undesired antimuscarinic and
sedative effects. It is used as an ingredient in cough or cold preparations.
|
| SALES
SPECIFICATION |
|
BASE
|
|
APPEARANCE
|
clear
to light yellow liquid |
|
PURITY
|
90.0%
min
|
|
BENZHYDROL |
2.0%
max
|
|
HYDROCHLORIDE
|
|
APPEARANCE
|
white
crystalline powder
|
|
PURITY
|
99.0%
min
|
|
pH
|
4
- 6
|
|
MELTING POINT |
167
- 172 C
|
|
LOSS
ON DRYING
|
0.5%
max |
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard Symbols: XN,
Risk
Phrases: 22, Safety Phrases: 36 |