ESTRADIOL

PRODUCT IDENTIFICATION
CAS NO. 50-28-2; 873662-39-6 (beta)
57-91-0 (alpha)

ESTRADIOL
EINECS NO. 200-023-8
FORMULA C18H24O2
MOL WT. 272.39

H.S. CODE

2937.92.0000

TOXICITY

 Rat LD (Subcutaneous):> 300mg/kg
SYNONYMS 3,17-beta-Dihydroxyoestra-1,3,5-triene; 17-beta-OH-estradiol;
1,3,5-Estratriene-3,17-beta-diol; 17-beta-Estra-1,3,5(10)-triene-3,17-diol; 17-beta-OH-oestradiol; 17-beta-Oestra-1,3,5(10)-triene-3,17-diol; Oestradiol; 17beta-Oestra-1,3,5(10)-triene-3,17-diol; 3,17-Epidihydroxyestratriene; 3,17-beta-Dihydroxy-1,3,5(10)-oestratriene; Estradiolum; 3,17-beta-Dihydroxyestra-1,3,5(10)-triene; 3,17-beta-Estradiol; Estradiol-17beta; 3,17-beta-Oestradiol; 3,17beta-Dihydroxyestra-1,3,5-triene; Dihydrofolliculin; Dihydrotheelin; Dihydroxyestrin; 3,17beta-Dihydroxyoestra-1,3,5-triene; Estra-1,3,5(10)-triene-3,17-beta-diol; Oestra-1,3,5(10)-triene-3,17-beta-diol; cis-estradiol; 3,17-epidihydroxyestratriene; Dihydrofollicular hormone; Estrovite; Femestral; Femogen; Gynergon; Gynestrel; Ovahormon; Ovocycline; Primofol; Progynon; Dimenformon; Dimenformon Prolongatum; Diogyn; 3,17-beta-Dihydroxy-1,3,5(10)-estratriene;
SMILES

C1[C@H]2[C@H]3[C@@H](c4c(cc(O)cc4)CC3)CC[C@@]2([C@H](O) C1)C

CLASSIFICATION

Steroid, Steroid Hormone, Estrogen, Estrogen Modulator, Biochemicals ex Plants, Hormone Antagonist.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 173 - 179 C
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER

practically insoluble (3.6 mg/l)

SOLVENT SOLUBILITY

soluble in alcohol, acetone and dioxane, sparingly soluble in vegetable oils
pH  
log Pow 4.01 (Octanol-water)
VAPOR PRESSURE 1.26E-08 (mmHg at 25 C)
HENRY'S LAW 3.64E-11 (atm-m3/mole at 25 C)
OH RATE 1.23E-10 (cm3/molecule-sec at 25 C Atmospheric)

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & EXTERNAL LINKS
Estrogen is a mammalian estrogenic hormone naturally produced by follicle cells of the vertebrate ovary, placenta, testis, and adrenal cortex. It is involved in implantation of the fertilized ovum, acceleration of maturation, and the maintenance of secondary sex characters and female reproductive organs such as mammary glands, uterus, vagina, and fallopian tubes. Estradiol is most potent mammalian estrogenic hormone. It is produced semi-synthetically for estrogen replacement therapy in the treatment of female hypogonadism, vasomotor symptoms, abnormal uterine bleeding, and primary ovarian failure. It is also used as a feed additive as a growth promoter. There are two isomers: estradiol-17beta (the principally active one) and estradiol-17alpha (inactive). It provokes ICSH (interstitial-cell-stimulating hormone) secretion and proliferation of the human endometrium. Estrogen includes

Estrogen

CAS RN
Diethylstilbestrol diphosphate 522-40-7
Equilin 474-86-2
Estradiol cypionate 313-06-4
Estradiol enanthate 4956-37-0
Estradiol undecylate 3571-53-7
Estradiol valerate 979-32-8
Estradiol 50-28-2
Estratab 12126-59-9
Estriol 50-27-1
Estrofurate 10322-73-3
Estrone Sodium Sulfate 438-67-5
Estrone 53-16-7
Estropipate 7280-37-7
Ethinyl estradiol 57-63-6
Fenestrel 7698-97-7
Mestranol 72-33-3
Nylestriol 39791-20-3
Quinestrol 152-43-2

Wikipedia Linking: http://en.wikipedia.org/wiki/Estradiol

http://biomarkers.uchicago.edu/
Estradiol (Salivary Estradiol Measurement in Wave I of the Social Life Health & Aging Project)

http://itech.dickinson.edu/

  • Estradiol is a sex hormone present in both females and males.
  • Estradiol is one of the three naturally occuring estrogens in females, along with estriol and estrone
  • It is present in women from puberty until menopause
  • It is essential for the reproductive system, as well as for sexual reasons
  • Affects many of the body’s major systems
  • Synthetic estradiol is used in the pill, for hormone replacement therapy in transsexuals, and for postmenopausal women
  • Estradiol is derived from cholesterol which is converted into androstenedione. Androstendione is then converted to testosterone which in turn is converted to estradiol
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

Pass Test A(IR), B(UV)

ASSAY
97.0 - 103.0%

OPTICAL ROTATION

 +76° ~ +83°

MELTING POINT

173 - 179 C

WATER

3.5% max

IMPURITY

Individual impurity 0.2% max, Total impurity 0.5% max
TRANSPORTATION
PACKING

 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 45-63, Safety Phrases: 53-26-36/37/39