| CAS
NO. |
50-03-3 |
|
| EINECS NO. |
206-684-1 |
| FORMULA |
C23H32O6 |
| MOL
WT. |
404.50 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
17-alpha-Hydroxycorticosterone
acetate; |
| 17-Hydroxycorticosterone-21-acetate;
21-Acetoxy-4-pregnene-11beta,17alpha-diol-3,20-dione; Cortisol 21-acetate;
Cortisol acetate; Hydrocortisone-21-acetate; 17-Hydroxycorticosterone
21-acetate; 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
21-acetate; 21-Acetoxy-4- pregnene-11beta, 17alpha-diol-3,20-dione; 4-Pregnene-11beta,17alpha,21-
triol-3,20- dione
21-acetate |
|
DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to off-white
crystalline powder |
| MELTING POINT |
223
C (Decomposes) |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Insoluble
(slightly soluble in alcohol and in chloroform) |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
APPLICATIONS
|
The term hydrocortisone is for cortisol (an adrenocortical steroid) when used as
a pharmaceutical. Cortisol is one of main hormones released by the body in
response to stress. It affects blood pressure and blood sugar levels and
regulates the immune system. It is involved in the metabolism of glucose,
protein, and fats. Synthetic hydrocortisone and its esters are used primarily
for their anti-inflammatory in allergic rashes, eczema and certain other
inflammatory conditions. It is used as an immunosuppressive in the treatment of
allergic and dermatologic disorders, adrenocortical insufficiency and many other
disorders.
- Hydrocortisone Base
(CAS
#: 50-23-7)
- Hydrocortisone
Aceponate (CAS
#: 74050-20-7)
- Hydrocortisone-17-butyrate-21-propionate (CAS
#: 72590-77-3)
- Hydrocortisone-21-hemisuccinate (CAS
#: 83784-20-7)
- Hydrocortisone-17-valerate (CAS
#: 57524-89-7)
- Hydrocortisone-17-propionate (CAS
#: 65980-97-4)
- Hydrocortisone-21-propionate (CAS
#: 6677-98-1)
- Hydrocortisone-21-valerate (CAS
#: 6678-00-8)
- Hydrocortisone-21-galactoside (CAS
#: 92901-25-2)
- Hydrocortisone-21-hemipimelate (CAS
#: 107085-84-7)
- Hydrocortisone-17-butyrate (CAS
#: 13609-67-1)
- Hydrocortisone-21-phosphate (CAS
#: 3863-59-0)
- Hydrocortisone-21-acetate (CAS
#: 50-03-3)
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white to off-white
crystalline powder |
|
ASSAY |
97.0
- 102.0% |
|
IDENTIFICATION
|
positive
(Test A, Test B,)
|
|
INDIVIDUAL
IMPURITY
|
0.5% max |
|
TOTAL
IMPURITY
|
1.0%
max
|
|
LOSS
ON DRYING
|
8.0%
max
|
|
OPTICAL ROTATION |
+158° ~
+165° |
|
SULFATED
ASH
|
1.0%
max
|
|
RESIDUE ON IGNITION |
|
|
RESIDUAL
SOLVENTS |
Total Solvents:
0.5% max
Acetone: 0.5% max
Methanol: 3000ppm
max
Methylene Chloride: 600ppm max |
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
|