PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

Stable under ordinary conditions.

APPLICATIONS

Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as osteoporosis, metastatic disease, and Paget's disease. While bisphosphonates are analogues of endogenous pyrophosphate structurally, they are characterized by a P-C-P bond, the linking oxygen is replaced with a carbon, which is resistant to enzymatic and chemical hydrolysis. General structure is

Side chains are responsible for chemical-physicla properties, mechanism of resorption, and pharmacokinetics. It is known that biphosphonates bind strongly to hydroxyapatite crystals at the sites of increased bone turnover preferentially and inhibit the formation, aggregation, and dissolution of the crystals.They also may inhibit osteoclast function directly, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
Bisphosphonate products include: (see below)

• Etidronic acid (CAS #: 2809-21-4)
• Clodronic acid (CAS #: 10596-23-3)
• Tiludronic acid (CAS #: 89987-06-4)
• Medronic acid (CAS #: 1984-15-2)
• Pamidronic acid (CAS #: 40391-99-9)
• Neridronic acid (CAS #: 79778-41-9)
• Olpadronic acid (CAS #: 63132-39-8)
• Alendronic acid (CAS #: 66376-36-1)
• Ibandronic acid (CAS #: 114084-78-5)
• Risedronic acid (CAS #: 105462-24-6)
• Zoledronic Acid (CAS #: 118072-93-8)

Medication members for the treatment of postmenopausal osteoporosis in women by building healthy bone and restoring some of the bone loss as a result of osteoporosis include vitamin D and calcium supplements, bisphosphonate drugs, certain selective estrogen receptor modulators, estrogen replacements and parathyroid hormones. Examples are below:

APPEARANCE

ASSAY

HEAVY METALS

PHOSPHITE

0.2% max

IMPURITY

0.5% max

ARSENIC

2ppm max

BISPHOSPHONATE PRODUCTS