| CAS
NO. |
60166-93-0;
60208-45-9; 62883-00-5 |
|
| EINECS NO. |
262-093-6 |
| FORMULA |
C17H22I3N3O8 |
| MOL
WT. |
777.09 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Jopamidol; (R)-Iopamidol;
Solutrast 370; |
| (S)-N,N'-bis(2-Hydroxy-1-(hydroxymethyl)ethyl)-2,4,6-triiodo-5-lactamidoisophthalamide;
L-(+)-N,N'-Bis(2-hydroxy-1-hydroxymethylethyl)-2,4,6-triiodo-5-lactamide
isophthalamide; L-5alpha-Hydroxypropionylamino-2,4,6-triiodoisophthalic
acid di(1,3-dihydroxy-2-propylamide); L-5alpha-Idrossipropionilamino-2,4,6-triiodoisoftal-di(1,3-diidrossi-2-propilamide);
N,N'-Bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-(((2S)-2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-
1,3-benzenedicarboxamide; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to off-white
crystalline powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
soluble |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
|
Contrast media is a substance that is introduced into or around a structure or
tissues to produce the visualization of organs and certain tissues under the
absorption of x-rays. In diagnostic radiology the purpose is to detect and to
treat certain diseases. Nonionizing radiations of infrared, gamma rays,
ultrasound waves, and magnetic fields are also used for diagnosis. MRI contrast
agents work by altering the magnetic properties of hydrogen nucleus not by
radioopaque. Barium sulfate class contrast agents are used in the digestive
tract. Organic iodine contrast agents are water soluble and less harmful to the
body, and thus can be used almost anywhere in the body.
Iopamidol
[(S)-N,N'-bis(2-Hydroxy-1-(hydroxymethyl)ethyl)-2,4,6-triiodo-5-lactamidoisophthalamide]
is a non-ionic, water-soluble, low-osmolality contrast agent which is used in
myelography, arthrography, nephroangiography, arteriography, and other
radiological procedures; administered intravenously or orally.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white powder |
|
IDENTIFICATION |
Passes
test A, B
|
|
ASSAY |
98.0 -
102.0% |
|
SPECIFIC ROTATION |
5.2°
~ 4.6°
|
|
LOSS ON DRYING |
0.5%
max
|
|
RESIDUE ON IGNITION |
0.1%
max
|
|
FREE AMINES |
0.02%
max
|
|
HEAVY METALS |
10ppm
max
|
|
SOLVENT RESIDUE |
10ppm
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
|