L-EPINEPHRINE

PRODUCT IDENTIFICATION
CAS NO. 51-43-4

L-EPINEPHRINE
EINECS NO. 200-098-7
FORMULA C9H13NO3
MOL WT. 183.20

H.S. CODE

  
TOXICITY

 
SYNONYMS Epinephrine;
(-)-(R)-Epinephrine; (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol; (R)-Adrenaline; (R)-Epinephrine; 1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; 1-Adrenalin; 1-Epinephrine; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; Adnephrine; Adrenal; Adrenalin; Adrenalina; Adrenaline; Adrenalinum; Adrenamine; Epinefrina; Epinephran; Epinephrinum; Methylaminoethanolcatechol; Methylarterenol; Nieraline; Paranephrin; R-(-)-Epinephrine; L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; L-Adrenaline; 4-[(1R)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish fine crystalline powder
MELTING POINT 208 - 211 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  

SOLVENT SOLUBILITY

  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Epinephrine, also known as adrenaline, is a sympathomimetic hormone secreted by the adrenal medulla and a neurotransmitter, a chemical released by a neuron at a synapse and acts as a electrical signal between a neuron and another cell. Epinephrine acts to stimulates both the alpha- and beta- adrenergic systems and increase blood pressure due to stimulation of heart action and constriction of peripheral blood vessels. It causes systemic vasoconstriction and gastrointestinal relaxation, and dilates bronchi and cerebral vessels. The synthetic Levo- form, usually used in the bitartrate salt, is used as a vasoconstricting adjunct to local or regional anesthesia, as a cardiac stimulant, vasopressor; as a systemic antiallergic. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. Tyrosine, phenolic alpha amino acid, is a precursor of the hormones such as epinephrine, norepinephrine, thyroxine, and triiodothyronine. Dopamine, a catecholamine neurotransmitter as a major transmitter in the extrapyramidal system in the brain, is an intermediate in epinephrine and norepinephrine biosynthesis. Metanephrine excreted in the urine is an inactive metabolite of epinephrine. Metanephrine is measured as a test for pheochromocytoma. Norepinephrine is the precursor of epinephrine. It is a major neurotransmitter that acts on both alpha- and beta-adrenergic receptors. It is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. The synthetic bitartrate salt of the Levo- norepinephrine is used as a vasoconstrictor and to restore the blood pressure in certain cases of acute hypotension, and to improve cardiac function during decompensation associated with congestive heart failure or cardiovascular surgery, administered intravenously. Epinephrine related molecular compounds are:

Product

CAS RN
Isoproterenol hydrochloride 51-30-9
Levisoprenaline 51-31-0
Norepinephrine bitartrate anhydrous 51-40-1
Norepinephrine 51-41-2
Epinephrine bitartrate 51-42-3
Epinephrine 51-43-4
Epinephrine hydrochloride 55-31-2
(±)-Noradrenaline hydrochloride 55-27-6
Adrenalone hydrochloride 62-13-5
Normetanephrine 97-31-4
Adrenalone 99-45-6
Protokylol 136-70-9
DL-Norepinephrine 138-65-8
Nordefrin hydrochloride 138-61-4
(±)-Isoproterenol 149-53-1
D-Norepinephrine 149-95-1
D-Epinephrine 150-05-0
Isoproterenol sulfate 299-95-6
DL-Epinephrine hydrochloride 329-63-5
Norepinephrine hydrochloride 329-56-6
Racepinephrine 329-65-7
Noradrenochrome 490-89-1
Noradrenalone 499-61-6
Deoxyepinephrine 501-15-5
Ethylnorepinephrine 536-24-3
N-Methylepinephrine 554-99-4
alpha-Methyldopamine 555-64-6
D-Noradrenaline bitartrate 636-88-4
Dichloroepinephrine 1892-72-4
4-Hydroxyphenylisopropylarterenol 2549-15-7
6-Hydroxynoradrenaline 2623-77-0
(+)-Isoprenaline 2964-04-7
Ethylnorepinephrine hydrochloride 3198-07-0
(±)-Norepinephrine bitartrate 3414-63-9
Metanephrine 5001-33-2
Epinephryl borate 5579-16-8
Nordefrin 6539-57-7
Isoproterenol 7683-59-2
Dioxifedrine 10329-60-9
Theodrenaline 13460-98-5
N-Cyclopentylbutanephrine 13725-15-0
N-Acetylarterenone 14522-07-7
(+)-Isoproterenol bitartrate 14638-70-1
alpha-Methylepinine 15398-87-5
Colterol 18866-78-9
DL-Epinephrine bitartrate 19947-47-8
Droxidopa 23651-95-8
N-Acetylnorepinephrine 30959-88-7
Norparanephrine 32655-70-2
Epinephrine maleate 36199-53-8
N,N-Dimethylepinephrine 38522-73-5
Isolevin 40915-50-2
D-Epinephrine hydrochloride 52134-32-4
Dipivefrin 52365-63-6
Adrenaline sulfate 52455-32-0
Levorenone 54958-67-7
Epinephrine glucuronide 54964-61-3
Pilaren 60996-13-6
Dipivefrin hydrochloride 64019-93-8
N-Butylepinephrine 64037-63-4
Dipivaloylnorepinephrine 65114-84-3
Ibopamine 66195-31-1
3-Fluoronorepinephrine 71144-40-6
Epinephrine sulfate 77469-50-2
Noradrenaline sulfate 81138-41-2
alpha-Methylepinephrine dipivalate 81497-25-8
6-Fluoronorepinephrine 86820-21-5
4-Pivaloylepinephrine 91264-45-8
3,4-Diisovaleryl adrenaline 92634-50-9
3,4-Diisovaleryl adrenalone 92634-49-6
Adrenaline carboxylic acid 92843-37-3
Renovaine 98523-34-3
Aminomenthylnorepinephrine 99081-68-2
Bromoacetylaminomenthylnorepinephrine 99081-70-6
Epinine 3-O-sulfate 101910-85-4
Epinine 4-O-sulfate 101910-86-5
Epinine 4-O-sulfate 101910-86-5
2-Chloronorepinephrine 101969-79-3
6-Chloronorepinephrine 101996-38-7
Fosopamine 103878-96-2
Norepinephrine bitartrate 108341-18-0

2-Fluoroepinephrine

109672-71-1
4-Fluorophenylephrine 109672-73-3
6-Fluorophenylephrine 109672-75-5
N-(4-Azido-3-iodophenethylamidoisobutyl)norepinephrine 117685-73-1
1-(3,4-Dihydroxyphenyl)-1,2-diaminoethane 132261-26-8
3-Pivaloylepinephrine 144750-97-0
SALES SPECIFICATION

APPEARANCE

 white to yellowish fine crystalline powder

ASSAY

97.0 - 103.0%
LOSS ON DRYING

1.0% max
SULFATED ASH

0.1% max
RESIDUE ON IGNITION

0.1% max
OPTICAL ROTATION -50° ~ -53° c=4, 1M HCl)
NOREPINEPHRINE 3.0% max
MELTING POINT 208 - 211 C

HEAVY METALS

20ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS 6.1 (Packing Group: II)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 23/24/25, Safety Phrases: 36/37/39-45