PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
Stable under ordinary conditions.
GENERAL DESCRIPTION & APPLICATIONS
Vitamin K is a group of compounds that are needed for the synthesis of certain proteins that help control bleeding. Vitamin K prevents bleeding by increasing hepatic biosynthesis of prothrombin and other coagulation factors. It is also needed for healthy bones. Vitamin K is a fat-soluble liquid that are biologically inactive when exposed to light or alkali. There are two forms naturally, phytonadione (vitamin K1) and menaquinone (vitamin K2). Phytonadione occurs in plants and is consumed in the diet. Menaquinone is produced by bacteria in the intestine. All of these compounds have the basic structure of methylated naphthoquinone and aliphatic side chain substituents. Phytonadione have its substituent of four isoprene units , one of which is unsaturated (phytyl substituent at 3 position). Menaquinones have side chains composed of a variable number of isoprene units; designated as MK-n, where n specifies the number of isoprene units.. The number of isoprene unit varies lipophilicity for the different function of intestinal absorption, transport, tissue distribution, and bio-availability. Menadione (vitamin K3) is a synthetic form which does not have aliphatic side chain. Menadione is a vitamin precursor of V-K2 which can be converted in the liver to active menaquinones by chemical alkylation in vivo. Menadione Is used as a source of vitamin K in the treatment of hypoprothrombinemia against vitamin K deficiency. It is not used directly as a nutritional supplement due to high toxicity and low stability. Menadione sodium bisulfite (MSB) is a water-soluble derivative of menadione for feed. But MSB has limited stability to light, heat, humidity, ambient pH values above neutrality and in the presence of some salts. Menadione dimethyl pyrimidinol bisulfite (MPB) and menadione nicotinamide bisulfite (MNB) are other synthetic forms that have higher stability nut low solubility in water than MSB.
Molecular compounds of vitamin K
| Menadione | 58-27-5 |
| 2-Methyl-4-amino-1-naphthol | 83-70-5 |
| Menadiol bis(dihydrogen phosphate) | 84-98-0 |
| Phytonadione | 84-80-0 |
| Menaquinone 6 | 84-81-1 |
| Menadione bisulfite | 130-36-9 |
| 2-Methyl-4-amino-1-naphthol hydrochloride | 130-24-5 |
| Menadione sodium bisulfite anhydrous | 130-37-0 |
| Menadiol sodium diphosphate anhydrous | 131-13-5 |
| Menadiol | 481-85-6 |
| N-(4-Hydroxy-3-methyl-1-naphthyl)acetamide | 523-68-2 |
| Menaquinone 9 | 523-39-7 |
| Menaquinone 8 | 523-38-6 |
| Menaquinone 10 | 523-40-0 |
| Phytonadiol | 572-96-3 |
| Acetomenaphthone | 573-20-6 |
| Phytonadiol diacetate | 604-87-5 |
| Menatetrenone | 863-61-6 |
| gamma-Hydroxyvitamin K | 1181-23-3 |
| 2-Chlorophylloquinone | 1258-63-5 |
| Menadiol sodium sulfate | 1612-30-2 |
| Menaquinone 7 | 2124-57-4 |
| Menadoxime | 6146-99-2 |
| Menadione sodium bisulfite trihydrate | 6147-37-1 |
| Menadiol sodium diphosphate hexahydrate | 6700-42-1 |
| Vitamin K2 | 11032-49-8 |
| Vitamin K1 | 11104-38-4 |
| Vitamin K | 12001-79-5 |
| Menadione dimethylpyrimidinol bisulfite | 14451-99-1 |
| Menadione epoxide | 15448-59-6 |
| Phytonadione hydroperoxide | 15576-39-3 |
| Phytonadione oxide | 25486-55-9 |
| Demethylmenaquinone | 29790-47-4 |
| 2,5-Dimethyl-2-(4,8,12-trimethyltridecyl)-2H-naphtho(1,2-b)pyran-6-ol | 34044-00-3 |
| Menadione semiquinone | 34524-96-4 |
| Phylloquinone aglycone II | 34927-45-2 |
| Tetrahydromenaquinone | 49852-77-9 |
| 3-Bromomethylmenadione | 50371-29-4 |
| Phylloquinone aglycone I | 51732-61-7 |
| Menadiol dibutyrate | 53370-44-8 |
| Menadione nicotinamide bisulfite | 73581-79-0 |
| Phylloquinone aglycone III | 77179-33-0 |
| Phytonadione epoxide-1,4-diol | 81382-12-9 |
| 3-Hydroxy-2,3-dihydrophytonadione | 82162-05-8 |
| Osteocalcin | 104982-03-8 |
| 2-Trifluoromethylmenaquinone | 119052-96-9 |
| 2-Trifluoromethylphylloquinone | 119052-95-8 |
APPEARANCE
IDENTIFICATION
Conforms
CONTENT
50.0% min
20ppm max
2.0% max