METHANDROSTENOLONE

PRODUCT IDENTIFICATION
CAS NO. 72-63-9

METHANDROSTENOLONE
EINECS NO. 200-787-2
FORMULA C20H28O2
MOL WT. 300.44

H.S. CODE

  

TOXICITY

 
SYNONYMS Metandienone; Methandienone;
17alpha-methyl-17beta-hydroxy-1,4-androstadien-3-one; 17beta-Hydroxy-17-methylandrosta- 1,4-dien-3-one; 1-Dehydro-17a-methyltestosterone;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 163 - 167 C
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER

practically insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions

APPLICATIONS
Testosterone is the major androgenic hormone that is responsible for the growth and development of masculine characteristics. It is produced in the Leydig cells (interstitial cells) of the testes. it regulates gonadotropic secretion and wolffian duct differentiation (formation of the epididymis, vas deferens, and seminal vesicle), and stimulates skeletal muscle. It is also responsible for other male characteristics and spermatogenesis after its conversion to dihydrotestosterone by 5alpha-reductase in peripheral tissue. Testosterone is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. In addition, testosterone possesses protein anabolic properties, manifested by retention of nitrogen, calcium, phosphorus, and potassium, and is important in maintaining muscle mass and bone tissue in the adult male. It is also converted by aromatization to estradiol in peripheral tissue. It has been synthesized for replacement therapy, in the form of various esters having prolonged duration of effects, in treating male hypogonadism, cryptorchidism, frigidity, inoperable female breast cancer, oligospermia, to suppress lactation, and as an anabolic agent. Esters administered by subcutaneous, intramuscular injection, buccally or intramuscularly include;

· Cloxotestosterone (CAS RN: 53608-96-1)
· Ethisterone (Ethynyl testosterone, CAS RN: 434-03-7)
· Mestanolone (CAS RN: 521-11-9)
· 17alpha-Methyltestosterone (CAS RN: 58-18-4)
· Norethindrone (CAS RN: 68-22-4)
· Normethisterone (CAS RN: 514-61-4)
· Oxymetholone (CAS RN: 434-07-1)
· Silandrone (Testosterone trimethylsilyl ether, CAS RN: 5055-42-5)
· Testosterone Acetate (CAS RN: 1045-69-8)
· Testosterone Phenylpropionate (CAS RN: 1255-49-8)
· Testosterone Benzoate (CAS RN: 2088-71-3)
· Testosterone heptanoate (CAS RN: 315-37-7)
· Testosterone phenylacetate (CAS RN: 5704-03-0)
· Testosterone propionate (CAS RN: 57-85-2)
· Testosterone cypionate (CAS RN: 58-20-8)
· Testosterone ketolaurate (CAS RN: 5874-98-6)
· Testosterone Undecanoate
· Testosterone Glucuronide
· Testosterone Hemisuccinate

Alkylated testosterone at 17-alpha position such as methyltestosterone show more pharmacologic activity than testosterone itself. Methyltestosterone, a synthetic androgen, is used to treat testosterone deficiency in males. For females it is used in the relief of postpartum breast pain and swelling after pregnancy. It is used to treat the symptom of menopause and in the palliation of certain inoperable breast cancers. Methyltestosterone is a white to creamy white crystalline powder; melting point 162 - 167 C; practically insoluble in water; soluble in various organic solvents; administered orally or sublingually. The chemical designation is 17beta-hydroxy-17alpha-methyl-4-androsten-3-one.

Methandrostenolone, dehydro form of methyltestosterone, is one of the most effective anabolic steroids. It is used in a therapy of chronic coronary deficiency, in selected cases of interstitial-pituitary insufficiency, ulcerous renal diseases following by loss of protein and azotemia, and in the adjunctive treatment of senile and postmenopausal osteoporosis. Methandrostenolone is a white to creamy white crystalline powder; melting point 163 - 167 C; practically insoluble in water; slightly soluble in ether; soluble in ethanol, acetic acid; administered orally. The chemical designation is 17beta-Hydroxy-17-methylandrosta-1,4-dien-3-one.
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

ASSAY
97.0 - 103.0%

OPTICAL ROTATION

 +7° ~ +11°

MELTING POINT

163 - 167 C

LOSS ON DRYING

0.5% max
TRANSPORTATION
PACKING

 
HAZARD CLASS 6.1 (Packing Group: II)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 45-63, Safety Phrases: 53-26-36/37/39