METHYL-beta-CYCLODEXTRIN

PRODUCT IDENTIFICATION
CAS NO.

128446-36-6

METHYL-beta-CYCLODEXTRIN

EINECS NO.  
FORMULA

 

MOL WT.

1310

H.S. CODE

  

TOXICITY

  
SYNONYMS beta-Methylcycloamylose cyclomaltoheptaose, methyl ether
Methylcycloheptaglucan beta-Methylcyclodextrin
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT

Decomposes (180 - 182 C)

BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER

> 200g in100 ml

pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 1 Flammability: 1 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under normal conditions. 

GENERAL DESCRIPTION & APPLICATIONS
Cyclic structure oligomers of glucose ( called cyclodextrins) are obtained from the starch digests of the bacteria Bacillus macerans. The individual glucose units are connected by 1,4 bonds. The most abundant cyclodextrins are alpha, beta and gamma cyclodextrin which have 6,7 and 8 glucose units respectively. The interior cavity is hydrophobic and the outside of the molecule is hydrophilic. The enhanced of characteristics such as stability, aqueous solubility, and reduced volatility, can be modified through mainly propoxylation reactions of them. Potential applications of cyclodextrins include water-soluble pharmaceuticals, prolonged drug release, tabletting and herbicides and pesticides.

Some examples of commercially available cyclodextrin, or derivatives thereof, are as follows:

  • alpha-Cyclodextrin (CAS #: 10016-20-3)
  • alpha-Cyclodextrin phosphate Sodium salt (CAS #: 199684-60-1)
  • alpha-Cyclodextrin, sulfated Sodium salt Hydrate (CAS #: 699020-02-5)
  • Hexakis (2,3,6-tri-O-acetyl)-alpha-cyclodextrin
  • Hexakis (2,3,6-tri-O-methyl)-alpha-cyclodextrin
  • Hexakis(2,3,6-tri-O-octyl)-alpha-cyclodextrin (CAS #: 140395-31-9)
  • Hexakis-6-bromo-6-deoxy-alpha-cyclodextrin (CAS #: 53784-82-0)
  • Hexakis-6-iodo-6-deoxy-alpha-cyclodextrin (CAS #: 131105-41-4)
  • Hexakis (6-O-tertbutyl-dimethylsilyl)-alpha-cyclodextrin
  • Butyl-alpha-cyclodextrin
  • Succinyl-alpha-cyclodextrin
  • (2-Hydroxypropyl)-alpha-cyclodextrin (CAS #: 128446-33-3)
  • beta-Cyclodextrin (CAS #: 7585-39-9)
  • beta-Cyclodextrin Hydrate (CAS #: 68168-23-0)
  • beta-Cyclodextrin phosphate Sodium salt (CAS #: 199684-61-2)
  • beta-Cyclodextrin sulfate
  • beta-Cyclodextrin, sulfated Sodium salt (CAS #: 37191-69-8)
  • Hydroxypropyl-beta-cyclodextrin (CAS #: 94035-02-6)
  • 6-Monodeoxy-6-monoamino-beta-cyclodextrin
  • 6-O-alpha-D-Glucosyl-beta-cyclodextrin (CAS #: 92517-02-7)
  • 6-O-alpha-Maltosyl-beta-cyclodextrin Hydrate (CAS #: 104723-60-6)
  • Heptakis-6-azido-6-deoxy-beta-cyclodextrin
  • Heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 196398-66-0)
  • Heptakis-(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 201346-23-8)
  • Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (CAS #: 51166-71-3)
  • Heptakis-(2,6-di-O-ethyl)-beta-cyclodextrin (CAS #: 111689-03-3)
  • Heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (CAS #: 55216-11-0)
  • Heptakis(2,3,6-tri-O-acetyl)-beta-cyclodextrin
  • Heptakis-(2,3,6-tri-O-benzoyl)-beta-cyclodextrin (CAS #: 23666-43-5)
  • Heptakis-(2,3,6-tri-O-ethyl)-beta-cyclodextrin (CAS #: 111689-01-1)
  • Heptakis-6-iodo-6-deoxy-beta-cyclodextrin (CAS #: 30754-23-5)
  • Heptakis-6-(dimethyl-tert-butylsilyl)-6-deoxy-beta-cyclodextrin
  • Heptakis-6-bromo-6-deoxy-beta-cyclodextrin
  • Monoacetyl-beta-cyclodextrin
  • Diacetyl-beta-cyclodextrin
  • Triacetyl-beta-cyclodextrin (CAS #: 23739-88-0)
  • Heptakis(3-O-acetyl-2,6-di-O-methyl)-beta-cyclodextrin (CAS #: 131889-29-7)
  • Heptakis-(6-O-maltosyl)-beta-cyclodextrin
  • Heptakis(6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 197587-31-8)
  • Heptakis(6-O-t-butyldimethylsilyl-2,3-di-O-acetyl)-beta-cyclodextrin
  • Succinyl-(2-hydroxypropyl)-beta-cyclodextrin
  • (2,6-Di-O-)ethyl-beta-cyclodextrin
  • (2-Carboxyethyl)-beta-cyclodextrin
  • (2-Hydroxyethyl)-beta-cyclodextrin (CAS #: 128446-32-2)
  • (2-Hydroxypropyl)-beta-cyclodextrin (CAS #: 128446-35-5)
  • Butyl-beta-cyclodextrin
  • Methyl-beta-cyclodextrin (CAS #: 128446-36-6)
  • Silyl((6-O-tert-butyldimethyl)-2,3,-di-O-acetyl)-beta-cyclodextrin
  • Succinyl-beta-cyclodextrin
  • gamma-Cyclodextrin (CAS #: 17465-86-0)
  • gamma-Cyclodextrin Hydrate (CAS #: 91464-90-3)
  • gamma-Cyclodextrin phosphate Sodium salt (CAS #: 199684-62-3)
  • Sulfopropyl-beta-cyclodextrin
  • Carboxymethyl-gamma-cyclodextrin
  • Octakis (2,3,6-tri-O-acetyl)-gamma-cyclodextrin
  • Octakis (2,3,6-tri-O-methyl)-gamma-cyclodextrin
  • Octakis (2,6-di-O-pentyl)-gamma-cyclodextrin
  • Octakis-6-(dimethyl-tert-butylsilyl)-6-deoxy-gamma-cyclodextrin
  • Octakis-6-bromo-6-deoxy-gamma-cyclodextrin (CAS #: 53784-84-2)
  • Octakis-6-iodo-6-deoxy-gamma-cyclodextrin (CAS #: 168296-33-1)
  • Octakis (6-O-t-butyldimethylsilyl)-gamma-cyclodextrin
  • Succinyl-gamma-cyclodextrin
  • (2-Hydroxypropyl)-gamma-cyclodextrin (CAS #: 128446-34-4)
  • Acetyl-gamma-cyclodextrin
  • Butyl-gamma-cyclodextrin
SALES SPECIFICATION
APPEARANCE white to off-powder

PURITY

97.0% min

CLARITY

Clear and colorless in aqueous solution

SPECIFIC ROTATION

 +157° ~ +168° (c=1 in H2O on dry basis)

REDUCED COMPOUNDS

0.5% max

FREE CYCLODEXTRIN

0.1% max

SOLVENT RESIDUE

10 ppm max ( Methanol, methyl chloride)

ACIDITY

1.5% max

CHLORIDE

0.5% max

SULFATES

0.1% max

LOSS ON DRYING

5.0% max
MICROBIOLOGICAL Standard Plate Count: 300 /g max.
Yeast and Mold: 100 /g max.
Salmonella: Negative / 25 g
Coliform: Negative /g

HEAVY METALS

5ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 24/25-28A-37-45

GENERAL DESCRIPTION OF DEXTRIN
Dextrin is a polymeric carbohydrate  which are formed during the hydrolysis of starch to sugars by heat, by acids, and by enzymes.  (Maltose, sucrose and lactose are disaccharides of same  empirical formula (C12H22O11) but are isomers differs from  in structure).  Dextrin and starch have the general formula, -[Cx(H2O)y)]n-  (y = x - 1), in which glucose units are joined to one another usually head-to-tail,  but dextrin has a smaller and less complex molecule than starch. Dextrin is soluble in water but is  precipitated by  alcohol. It's  chemical properties  rely on  the  extent of  the starch from which they are derived.  Some dextrin  react with iodine to give a  blue color  and is soluble in 25% alcohol (called amylodextrin)   others a reddish-brown color  and  soluble in 55% alcohol (called erythrodextrin) and still others yield no color at all with iodine and  soluble in 70% alcohol (called achrodextrin). It is  also  identified  by dextrose equivalence (DE) which  is a measure of reducing power compared to the  standard of  100 (dextrose). The higher DE is the more extent of starch depolymerization. Maltodextrin is the product of low DE. Dextrin forms a strongly adherent paste when mixed with water and it is  used as adhesive in the manufacture of gummed tapes, textiles  and paper. It is used in producing nutritional products.