NEVIRAPINE

PRODUCT IDENTIFICATION
CAS NO. 129618-40-2

NEVIRAPINE

EINECS NO.  
FORMULA C15H14N4O
MOL WT. 266.30

H.S. CODE

  

TOXICITY

  
SYNONYMS Viramune; NVP;
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one; 6,11-Dihydro-11-cyclopropyl-4-methyldipyrido (2,3-b,2',3'-e)(1,4,)-diazepin-6-one;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white or off-white crystalline powder

MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble (Soluble in chloroform, slightly soluble in lower alcohol)
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 Health: 1; Flammability: 1; Reactivity: 0

AUTOIGNITION

 

FLASH POINT

112 C

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 (human immunodeficiency virus-1). Reverse transcriptase is an enzyme that  can transcribe RNA into DNA to copy genetic information from RNA to DNA, therefore also called RNA-directed DNA polymerase. Reverse transcriptase inhibitor is an antiretroviral agent that blocks activity of the reverse transcriptase of a retrovirus. Every retrovirus has a reverse transcriptase enzyme which transcribes the genetic information from its RNA into DNA. Protease inhibitors are the second class of antiretroviral drugs for the treatment of HIV.

Aantiretroviral agents

  • Non-nucleoside reverse transcriptase inhibitors
    • Delavirdine [CAS #: 136817-59-9]
    • Delavirdine mesylate [CAS #: 147221-93-0]
    • Efavirenz [CAS #: 154598-52-4]
    • Nevirapine [CAS #: 129618-40-2]
  • Nucleoside/Nucleotide reverse transcriptase inhibitors
    • Abacavir [CAS #: 136470-78-5]
    • Abacavir succinate [CAS #: 168146-84-7]
    • Abacavir sulfate [CAS #: 188062-50-2]
    • Adefovir [CAS #: 106941-25-7]
    • Adefovir dipivoxil [CAS #: 142340-99-6]
    • Combivir (Lamivudine/Zidovudine mixture) [CAS #: 165456-81-5]
    • Didanosine [CAS #: 69655-05-6]
    • Emtricitabine [CAS #: 143491-57-0]
    • Lamivudine [CAS #: 134678-17-4]
    • Lamivudine sulfoxide [CAS #: 160552-55-6]
    • Pradefovir mesylate [CAS #: 625095-61-6]
    • Stampidine [CAS #: 217178-62-6]
    • Stavudine [CAS #: 3056-17-5]
    • Tenofovir [CAS #: 147127-20-6]
    • Tenofovir disoproxil [CAS #: 201341-05-1]
    • Tenofovir Disoproxil Fumarate [CAS #: 202138-50-9]
    • Trizivir (Abacavir sulfate/Lamivudine/Zidovudine mixture) [CAS #: 364057-50-1]
    • Zalcitabine [CAS #: 7481-89-2]
    • Zidovudine [CAS #: 30516-87-1]
    • Zidovudine sodium salt [CAS #: 106060-86-0]
  • Protease inhibitors
    • Amprenavir [CAS #: 161814-49-9]
    • Atazanavir [CAS #: 198904-31-3]
    • Atazanavir sulfate [CAS #: 229975-97-7]
    • Fosamprenavir [CAS #: 226700-79-4]
    • Fosamprenavir calcium [CAS #: 226700-81-8]
    • Fosamprenavir sodium [CAS #: 226700-80-7]
    • Indinavir [CAS #: 150378-17-9]
    • Indinavir hydrate [CAS #: 180683-37-8]
    • Indinavir Sulfate [CAS #: 157810-81-6]
    • Kaletra (Lopinavir/Ritonavir mixture) [CAS #: 369372-47-4]
    • Lopinavir [CAS #: 192725-17-0
    • Nelfinavir [CAS #: 159989-64-7]
    • Nelfinavir mesylate [CAS #: 159989-65-8]
    • Ritonavir [CAS #: 155213-67-5]
    • Saquinavir [CAS #: 127779-20-8]
    • Saquinavir mesylate [CAS #: 149845-06-7]
    • Tipranavir [CAS #: 174484-41-4]
    • Tipranavir disodium [CAS #: 191150-83-1]
SALES SPECIFICATION

APPEARANCE

white or off-white crystalline powder
IDENTIFICATION

pass Test A (IR), B (HPLC)

ASSAY

98.0 - 102.0%

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

10ppm max

SOLVENT RESIDUE

0.2% max (EtOH)
RELATED SUBSTANCES Individually 0.2% max / Total 0.5% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION