NORDIHYDROGUAIARETIC ACID

PRODUCT IDENTIFICATION
CAS NO. 500-38-9

NORDIHYDROGUAIARETIC ACID
EINECS NO. 207-903-0
FORMULA (CH(CH3)CH2C6H3(OH)2)2
MOL WT. 302.36

H.S. CODE

 2907.29.9000

TOXICITY

 Oral rat LD50: 2000mg/kg
SYNONYMS Nordihydroguaiaretic acid; Masoprocol; NDGA;
2,3-Bis(3,4-dihydroxyphenylmethyl)butane; 2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol); 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol); 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane; Dihydronorguaiaretic acid; Dihydrodinorguaiaretic acid; Nordihydroguaiaretic acid; 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol;
SMILES

c1(ccc(O)c(c1)O)C[C@@H]([C@@H](Cc1cc(c(cc1)O)O)C)C

CLASSIFICATION

Phytochemical, Antioxidant, Analgesic, Anti-Inflammatory, Enzyme Inhibitor, Phenylpropanoid

EXTRA NOTES

 A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [MeSH]

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT 180 - 185 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS Health: 2; Flammability: 0; Reactivity 0

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Nordihydroguaiaretic acid

Wikipedia Linking - Nordihydroguaiaretic acid

Google Scholar Search - Nordihydroguaiaretic acid

U.S. National Library of Medicine - Nordihydroguaiaretic acid

PubChem Compound Summary - Nordihydroguaiaretic acid

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Nordihydroguaiaretic acid

http://www.ebi.ac.uk/chebi/ -  Nordihydroguaiaretic acid

http://www.ncbi.nlm.nih.gov/ -  Nordihydroguaiaretic acid

EPA - Substance Registry Services - Nordihydroguaiaretic acid

Local
Nordihydroguaiaretic Acid is used to prevent formation of eicosanoids, prostaglandins, thromboxanes, hydroxyeicosatetraenoic acid and various leukotrienes. It combines with lipoxygenase or cyclooxygenase and thereby serves as a lipoxygenase or cyclooxygenase inhibitor which prevent the substrate-enzyme combination with arachidonic acid. Nordihydroguaiaretic Acid is also known as an antioxidant which inhibit or retard the oxidation of a substance. It also used as an antioxidant in fats and oils.

SALES SPECIFICATION

APPEARANCE

 white to off-white powder
MELTING POINT

175 - 185 C

ASSAY

98.0% min

OPTICAL ROTATION

-1° ~ +1°

RESIDUE ON IGNITION

0.1% max

LOSS ON DRYING

0.5% max

HEAVY METALS

20ppm max

TOTAL MOLD/YEAST

Aerobic Plate Count: 100 organisms/g
Staphylococcusaureus: Negative
Candida albicans: Negative
Aspergllus species: Negative
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

GHS

 

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H302-H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

22-36/37/38

SAFETY PHRASES

26-36/37