PANTETHINE

PRODUCT IDENTIFICATION

CAS NO. 303-05-9; 16816-67-4

PANTETHINE

EINECS NO. 240-842-8
FORMULA C22H42N4O8S2
MOL WT. 554.72

H.S. CODE

 
DERIVATION

 

TOXICITY

 
SYNONYMS D-Bis(N-pantothenyl-2-aminoethyl)-disulfide; D-Pantethine;
(R-(R',R'))-N,N'-(Dithiobis(ethyleneimino(3-oxopropane-3,1-diyl))) bis(2,4-dihydroxy-3,3- dimethylbutyramide); N,N'-(Dithiobis(2,1-ethanediylimino(3-oxo-3,1-propanediyl)))bis(2- ,4-dihydroxy-3,3-dimethyl butanamide; Bis(pantothenamidoethyl) disulfide; Bis(N-pantothenylamidoethyl) disulfide;

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE clear to yellowish liquid
MELTING POINT

 

BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER readily Soluble (soluble in lower alcohol)
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 1 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under normal conditions. Hygroscopic.

GENERAL DESCRIPTION & APPLICATIONS

Pantothenic acid, the amide of beta-alanine and pantoic acid, is a B complex vitamin acting as a precursor in the biosynthesis of coenzyme A, involved in the metabolism as an antioxidant to breakdown many biochemical substances (fatty acids, steroids, phospholipids, heme, amino acids, and carbohydrates). The adrenal gland is an important site of pantothenic acid activity. It can be found ubiquitously in foods, and no deficiency syndrome has been demonstrated in humans except by experimental administration of the pantothenic acid antagonist (omega-methylpantothenic acid). Pantothenic acid is an unstable oil. The usual forms for feed supplementation are its salts, calcium D-pantothenate, sodium D-pantothenate and D-panthenol (liquid). Both salts are white hygroscopic powders easily soluble in water. D-Panthenol is a colourless viscous oil form which may turn to crystalline solid during storage (Racemic mixture is a solid form melting point 65C). Two enantiomers exit, D or L-form. D-panthenol is biologically active. But both forms show moisturizing properties. Panthenol is the alcohol analog of pantothenic acid. Panthenol is converted to pantothenic acid in the body. Panthenol is called provitamin B5. It is freely soluble in water, methanol and propylene glycol, soluble in ether and chloroform, slightly soluble in glycerin, insoluble in white oils and fats. Panthenol is absorbed into hair and skin to enhance thickening and moisturization effects and to stimulate healing of the lesions of various dermatologic lesions. It is widely used in hair care products and personal care products. It is used to increase peristalsis in atony and paralysis of the lower intestine and to help relieve gas retention and abdominal distention; administered intravenously or intramuscularly and orally.

Pantetheine [2,4-Dihydroxy-N-(2-((2-merceptoethyl)carbamoyl)ethyl)-3,3-dimethylbutyramide] is the amide analogue of pantothenic acid. Pantethine (bis-pantetheine) is formed naturally when reacted with beta-mercaptoethanolamine. This amide is an intermediate in the in the pathway of coenzyme A biosynthesis. Pantenicate [3-(3-Pyridinemethoxycarbonyl) propionic acid pantethine tetraester] is used as an antilipemic agent to reduce lipid levels in the blood (to treat hyperlipidemia).

PANTOTHENIC ACID MOLECULES

Product

CAS RN

alpha-Hydroxyhomopantothenic acid 1977-34-0
beta-Hydroxyhomopantothenic acid 1977-35-1
Calcium 4-phosphopantothenate 55816-28-9
Calcium D-pantothenate 15773-29-2
Calcium gamma-aminobutyratopantothenate 85625-91-8
Calcium hopantenate 17097-76-6
Calcium pantothenate hydrate 63409-48-3
Calcium Pantothenate racemic 6381-63-1
Calcium pantothenate 137-08-6
Calcium pantothenate, calcium chloride complex 6363-38-8
Chloramphenicol pantothenate complex 31342-36-6
Copper gamma-aminobutyratopantothenate 85625-88-3
Dexpanthenol 81-13-0
Dihydrostreptomycin pantothenate 3563-84-6
DL-Pantothenic acid 599-54-2
D-Panthothenyl trifarnesylacetate 15470-06-1
D-Pantothenamide 7757-97-3
D-Pantothenic acid 4'-O-beta-glucoside 29588-37-2
Homopantothenic acid 1977-33-9
Hopantenic acid 18679-90-8
Kanamycin dipantothenate 17899-96-6
Kanamycin monopantothenate 17899-71-7
L-Arginine pantothenate 23541-09-5
Manganese gamma-aminobutyratopantothenate 85625-90-7
Methyl pantothenate 50692-78-9
N-D-(+)-Pantothenoyl-gamma-aminobutyric acid 85647-53-6
Neomycin pantothenate 78149-94-7
Nickel gamma-aminobutyratopantothenate 85625-89-4
omega-Methyl pantothenic acid 2545-82-6

Pantetheine

496-65-1
Pantethine 16816-67-4
Pantethine 4',4''-diphosphate 2664-64-4
Pantenicate 96922-80-4
Panthenol 16485-10-2
Pantothenate ion 20938-62-9
Pantothenate permease 99194-01-1
Pantothenic acid 79-83-4
Pantothenylcysteine 4'-phosphate 7196-09-0
Pantoyltaurine 2545-84-8
Phosphopantothenic acid 5875-50-3
S-Benzylisothiouronium pantothenate 63680-25-1
Sodium omega-methyl pantothenate 59203-09-7
Sodium pantothenate 867-81-2
Streptomycin-pantothenate 6227-52-7
Viomycin pantothenate sulfate 1401-79-2
Zinc pantothenate 65979-81-9

SALES SPECIFICATION
APPEARANCE clear to yellowish liquid

PURITY

98.0% min (dry basis)

SPECIFIC ROTATION

+15° ~ +18°

WATER

18.0% min

ARSENIC

1ppm max

RELATED IMPURITY

1.0% max (total)

LOSS ON DRYING

1.0% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION