SPECTINOMYCIN

Synonyms. Spectinomycin; Decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano (2,3-b) (1,4)benzodioxin-4-one dihydrochloride pentahydrate; Trobicin; Spectogard; Spectam; Trobicin; Spectinomycin hydrochloride; Togamycin dihydrochloride pentahydrate; Actinospectacin; Trobicin; Togamycin; Spectam; Espectinomicina

SPECTINOMYCIN

 

PRODUCT IDENTIFICATION

CAS RN

1695-77-8 (base)
21736-83-4 (dihydrochloride, anhydrous)
22189-32-8 (dihydrochloride pentahydrate)

EINECS RN

216-911-3

FORMULA

 C14H24N2O7·2HCl·5H2O

MOLE WEIGHT

495.35

H.S CODE

 2941.90.1010

SMILES

 O1[C@H]2[C@H](O[C@@H]3O[C@H](C)CC ([C@@]13O)=O)[C@H]([C@H ](NC)[C@@H]([C@@H]2NC )O)O

CLASSIFICATION

Antibacterial, Anti-Infective, Aminoglycoside

EXTRA NOTES

 An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white crystalline powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Soluble

SOLVENT SOLUBILITY Soluble in methanol, ethanol, isopropanol, ethylene glycol, acetone, formamide

VAPOR DENSITY

 

log P(octanol-water)

 -0.82

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions. Hygroscopic and light sensitive

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 3,Flammability: 0, Reactivity: 1

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Spectinomycin

Google Scholar Search - Spectinomycin

Drug Information Portal (U.S. National Library of Medicine) - Spectinomycin

PubChem Compound Summary - Spectinomycin

Drug Bank -  Spectinomycin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Spectinomycin

http://www.ebi.ac.uk/ - Spectinomycin

http://www.ncbi.nlm.nih.gov/ - Spectinomycin

http://www.sci.sdsu.edu/
Antibiotic sensitivity and resistance. - Spectinomycin inhibits protein synthesis by binding to the Sr protein of the 30s ribosomal subunit and blocking translation. Spectinomycin resistance can arise via a single base substitution in the chromosomal gene encoding this ribosomal protein (rpsE). Plasmid encoded resistance to both spectinomycin and streptomycin can arise via modification of the antibiotics – for example, the aad gene transfers an adenyl group from ATP to these antibiotics which inactivates the antibiotic.

http://www.jbc.org/
Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

Local
SPECTINOMYCIN DERIVATIVES:

Product

CAS RN
Spectinomycin 1695-77-8
Spectinomycin dihydrochloride 21736-83-4
Spectinomycin dihydrochloride pentahydrate 22189-32-8
Spectinomycin monohydrochloride 22193-75-5
Spectinomycin sulfate 23312-56-3
Dihydrospectinomycin 28048-39-7
Lincospectin 57456-42-5
Spectinomycin sulfate tetrahydrate 64058-48-6
Tetrahydrospectinomycin 72244-45-2
4-Amino-4-dihydrospectinomycin 72748-69-7
3'-Aminomethyldihydrospectinomycin 87903-99-9
N,N'-Dibenzyloxycarbonyl-3'-spectinomycin cyanohydrin 87904-11-8
Trospectomycin 88669-04-9
Spenolimycin 95041-97-7
Homospectinomycin 97187-32-1
Trospectomycin sulfate 97673-66-0
Trospectinomycin 6-(5'-adenylate) 118428-06-1
Homospectinomycin dihydrochloride 119817-77-5

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

Conform

POTENCY (DRIED)

760µ/mg

ASSAY (WET)

620µ/mg

PH

4 ~ 5

WATER

18.0 ~ 19.0%

RESIDUE ON IGNITION

1.0% max

OPTICAL ROTATION

+18 ±1°

HEAVY METALS

20ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Not known. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed.

EC DIRECTIVES

 

HAZARD CODES

Xn

RISK PHRASES

 36/37/38

SAFETY PHRASES

 26-37/39

 

PACKING