SPIRONOLACTONE

PRODUCT IDENTIFICATION
CAS NO. 52-01-7

SPIRONOLACTONE
EINECS NO. 200-133-6
FORMULA C24H32O4S
MOL WT. 416.57

H.S. CODE

 2937.29.9090

TOXICITY

 
DERIVATION

 
SYNONYMS Spironolactonum; Spirolactone;
17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone acetate; 3'-(3-Oxo-7-alpha-acetylthio-17-beta-hydroxyandrost-4-en-17-beta-yl)propionic acid lactone; 3-(3-Keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid lactone; Espironolactona; Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan); 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone; Aldactone; Berlactone; Deverol; Diatense; Espironolactona; Euteberol; Spiresis; Spiridon; Spironolactonum; Uractone; Urusonin; Verospiron; Verospirone; Xenalon; Other RN: 496916-40-6, 1050678-93-7
SMILES

[C@@]12([C@@]3([C@@H](CC1)[C@H]1[C@H](CC3)[C@@]3(C(= CC(=O)C C3) C[C@H]1SC(=O)C)C)C)OC(=O)CC2

CLASSIFICATION

Aldosterone antagonist, Diuretic, Expectorant, Hormone Antagonist, Natriuretic

EXTRA NOTES

 Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.
Overall Carcinogenic Evaluation: Group 3

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT 134 - 136 C
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER

22 mg/l
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 1 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Spironolactone

Google Scholar Search - Spironolactone

Drug Information Portal (U.S. National Library of Medicine) - Spironolactone

PubChem Compound Summary - Spironolactone

Drug Bank -  Spironolactone

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Spironolactone

http://www.ebi.ac.uk/ - Spironolactone

http://www.ncbi.nlm.nih.gov/ - Spironolactone

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Spironolactone

Local:
Spironolactone is a is a synthetic 17-lactone steroid belong to a class of drugs called potassium-sparing diuretics which inhibit the exchange of sodium for potassium and hydrogen ions in the distal tubule. It acts as a competitive aldosterone antagonist in the distal renal tubules. Anti-androgen effect is also utilized as a component of hormone replacement therapy for transgender, in the treatment of hair loss, female hirsutism and acne but it can lead to adverse effects. Spironolactone, as a potassium-sparing diuretic, increases the secretion of water and sodium, while decreasing the excretion of potassium. Aldosterone synthesis is stimulated by increased plasma angiotensin II or potassium levels, which are present in proportion to plasma sodium deficiencies. Spironolactone is mainly used in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hypokalemia. Spironolactone itself is a weak diuretic, and it is used in combination with other diuretics. Angiotensin II antagonist such as valsartan, eprosartan and telmisartan decrease the effects of aldosterone and used as antihypertensive. Members of aldosterone antagonists include;

Aldosterone Antagonist

CAS RN
17alpha-Hydroxy-6beta,7beta-methylene-3-oxo-D-homo-17aalpha-pregna-4,16- dien-21- carboxylic acid 81844-75-9
17beta-Hydroxy-12-alpha-etiojerv-4-en-3-one 22785-18-8
17-Hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, 7-(1-methylethyl) ester potassium 41020-87-5
17-Hydroxy-3-oxo-19-nor-17alpha-pregn-4-ene-21-carboxylic acid gamma-lactone 1722-54-9
18-Deoxyaldosterone 2507-88-2
3,20-Dioxopregn-4-ene-18'-carboxaldehyde cyclic 18'-(1,2-ethandiylmercaptal) 123376-04-5
5-Oxo-A-tetranor-17-alpha-pregna-9,11-diene-21-17-carbolactone 76225-44-0
6,7-Epoxycanrenone 114577-01-4
7alpha-(Methylthio)spironolactone S-oxide 38753-75-2
7alpha-Thiospironolactone 38753-76-3
7-Thiomethylspirolactone 38753-77-4
Aldatense 76270-05-8
Canrenoate Potassium 2181-04-6
Canrenone 976-71-6
Dicirenone 41020-79-5
Dihydroxy-6,7-dihydrocanrenone 67483-35-6
Drospirenone 67392-87-4
Eplerenone 107724-20-9
Mespirenone 87952-98-5
Mexrenoate potassium anhydrous 41020-67-1
Mexrenoate potassium 43169-54-6
Mexrenone 41020-65-9
Oxprenoate potassium 76676-34-1
Prorenoate 49848-01-3
Prorenoate potassium 49847-97-4
Prorenone 49848-04-6
Spironolactone 52-01-7
Spirorenone 74220-07-8
SALES SPECIFICATION

APPEARANCE

 white to yellowish crystalline powder

IDENTIFICATION

Pass Test A, B, C

ASSAY
97.0 - 103.0%

OPTICAL ROTATION

 -37° ~ -33°

MELTING POINT

134 - 136 C

LOSS ON DRYING

0.5% max

CHLORIDE

50ppm max

SULFATED ASH

0.1% max
CANRENONE

1.0% max

IMPURITY

1.0% max
TRANSPORTATION
PACKING

 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

Harmful. May be harmful if swallowed. This substance has caused adverse reproductive and fetal effects in animals. May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This substance has caused reproductive effects in humans. This product contains spironolactone, a substance known to the state of California to cause cancer. Target Organs:Kidney, Male reproductive system., Female reproductive system., Bone marrow, Skin 

GHS

 
SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H360

P STATEMENTS

P201-P308 + P313
EC DIRECTIVES

 
HAZARD CODES

RISK PHRASES

60

SAFETY PHRASES

53-22-36/37/39-45
PRICE INFORMATION