| CAS
NO. |
57-68-1 |
|
| EINECS
NO. |
200-346-4 |
| FORMULA |
C13H15N3O2S |
| MOL
WT. |
277.34 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Sulfadimethyldiazine; sulfadimethylpyrimidine;
|
|
2-(p-aminobenzenesulfonamido)-4,6-dimethylpyrimidine;
sulfadine;
sulfa-isodimerazine;
2-Sulfanilamido-4,6-dimethylpyrimidine; sulfadimezine; sulfaisodimidine; Sulfamethazine; Sulfamethiazine;
sulfamethin; Sulfamezathine; sulfisomidon; sulfodimesin;
Sulfadimerazine;
4,6-dimethyl-2-sulfanilamidopyrimidine;
N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide;
4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)-Benzenesulfonamide;
N-(4,6-dimethyl-2-pyrimidyl) Sulfanilamide; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white crystalline powder |
| MELTING POINT |
197 - 200 C |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL DESCRIPTION
& APPLICATIONS
|
Sulfonamide is an organic sulfur compounds containing the radical -SO2NH2 (the
amides of sulfonic acids). Its molecular structure is similar to
p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a
substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of
interfering with the metabolic processes in bacteria that require PABA. They act
as antimicrobial agents by inhibiting bacterial growth and activity and called
sulfa drugs. They are used in the prevention and treatment of bacterial
infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug
includes;
- Topical sulfonamides: sulfacetamide; silver
sulfadiazine; mafenide;
- Rapidly absorbed and eliminated
sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole;
- Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole;
sulfasalazine; sulfaguanidine;
- Long lasting sulfonamides: sulfadoxine;
- Others: sulfamazole; sulfamazone;
sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole;
|
| SALES
SPECIFICATION (BP/USP) |
|
APPEARANCE
|
white crystalline powder |
|
IDENTIFICATION |
Complies |
|
ASSAY
|
99.0
- 101.0% (on dry basis)
|
|
ACIDITY |
0.3%
max
|
|
LOSS ON DRYING |
0.5%
max
|
|
RELATED
SUBSTANCE
|
0.5%
max
|
|
SOLUTION
CLARITY
|
Y5, BY3 or GY5
|
|
HEAVY
METALS
|
20ppm
max
|
| TRANSPORTATION |
| PACKING |
25kgs
in fiber drum |
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard Symbols: XI, Risk Phrases: 36/37/38-43, Safety Phrases: 26-36 |