TICARCILLIN DISODIUM

PRODUCT IDENTIFICATION
CAS NO 4697-14-7, 34787-01-4 (parent)
74682-62-5 (disodium salt)

TICARCILLIN DISODIUM
EINECS NO. 252-213-5
FORMULA C15H14N2Na2O6S2
MOL WT. 428.38

H.S. CODE

  

TOXICITY

  
SYNONYMS Ticarcilina; Ticarcilline; Ticarcillinum; 
N-(2-Carboxy-3,3-dimethyl -7-oxo-4-thia-1-azabicyclo[3.2.0] hept-6-yl)-3-thio- phenemalonamic acid; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6- ((carboxy-3-thienylacetyl)amino)- 3,3- dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S')))-; 6-((Carboxy-3-thienylacetyl)amino)-3,3- dimethyl-7-oxo-4- thia-1-azabicyclo(3.2.0) heptane-2-carboxylic acid.
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER  
pH 6 - 8
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 
FLASH POINT

 
STABILITY Stable under ordinary conditions.

APPLICATIONS
Ticarcillin is a semisynthetic broad-spectrum beta-lactam antibiotic effective against both gram-negative and gram-positive organisms, derived from penicillin similar to carbenicillin in action. It is derived from the basic penicillin nucleus, 6-amino-penicillanic acid. The chemical designation is 6-((Carboxy-3-thienylacetyl) amino)-3,3- dimethyl-7-oxo-4- thia-1-azabicyclo (3.2.0)heptane-2-carboxylic acid. It is used primarily in the treatment of severe systemic infections, septicemia, and infections of the genitourinary tract, the respiratory tract, or the soft tissues due to susceptible strains of bacteria. It should be used only to treat infections by bacteria. It will not treat viruses, including the flu. Ticarcillin is combined with potassium clavulanate to maintain the effectiveness against resistance to beta-lactam antibiotics. Ticarcillin disodium is administered intramuscularly or intravenously.

Beta-lactamase enzymes are produced by some bacteria and have resistance ability to beta-lactam antibiotics. These enzymes deactivate the antibacterial properties of beta-lactam antibiotics by opening the beta-lactam ring. Beta-lactamase inhibitors have little antimicrobial functions themselves and are combined with an actual beta-lactam antibiotic. Beta-lactamase inhibitors' function is to bind beta-lactamase enzymes to form an inactive molecule so that the actual beta-lactam antibiotic access to the bacterial wall which it destroys. Beta-lactamase inhibitors include clavulanic acid, sulbactam, and tazobactam.

SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

passed
ASSAY 800 µg/mg (on the anhydrous basis) min
TICARCILLIN CONTENT 80.0 - 94.0 % (on the anhydrous basis)
BACTERIAL ENDOTOXINS 0.05 EU/mg max

OPTICAL ROTATION

 +172º ~ +187º

WATER

 
TRANSPORTATION
PACKING
5kgs in drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION