gamma-BUTYROLACTONE

PRODUCT IDENTIFICATION

CAS NO.

96-48-0

GAMMA-BUTYROLACTONE

EINECS NO. 202-509-5
FORMULA C4H6O2
MOL WT.

86.09

H.S. CODE

2932.20.5010

TOXICITY

Oral rat LD50: 1580 mg/kg
SYNONYMS 4-Hydroxybutyric Acid Lactone; 4-Butanolide; GBL;
1,4-Butanolide; Butyric acid lactone; Butyrolactone; 4-Butyrolactone; Tetrahydro-2-Furanone Dihydro-2(3H)-Furanone; Hydroxybutanoic acid lactone; Butyrylactone; Dihydro-2(3H)-furanone; 4-Deoxytetronic acid; 4-Hydroxybutyric acid gamma-lactone; gamma-Hydroxybutyric acid cyclic ester; gamma-Hydroxybutyric acid lactone; Tetrahydro-2-furanone; 1,4-Lactone; sigma-Butyrolactone;
SMILES

C1(=O)CCCO1

CLASSIFICATION

Solvent, Lactone, Tetrahydrofuran

EXTRA NOTES

One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.[MeSH]
Overall Carcinogenic Evaluation: Group 3

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE clear liquid, mild odor
MELTING POINT -43 C
BOILING POINT

206 C

SPECIFIC GRAVITY 1.125-1.130
SOLUBILITY IN WATER Miscible
pH  
VAPOR DENSITY

3.0

AUTOIGNITION 455 C

REFRACTIVE INDEX

1.436-1.437
NFPA RATINGS Health: 2; Flammability: 1; Reactivity: 0
FLASH POINT

98 C

STABILITY Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - gamma-Butyrolactone

Wikipedia Linking - gamma-Butyrolactone

Google Scholar Search - gamma-Butyrolactone

U.S. National Library of Medicine - gamma-Butyrolactone

PubChem Compound Summary - gamma-Butyrolactone

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  gamma-Butyrolactone

ChEBI (http://www.ebi.ac.uk/chebi/) -  gamma-Butyrolactone

NCBI (http://www.ncbi.nlm.nih.gov/) -  gamma-Butyrolactone

Material Safety Data Sheet - gamma-Butyrolactone

Human Metabolome Database - gamma-Butyrolactone

Hazardous Substances Data Bank - gamma-Butyrolactone

EPA - Substance Registry Services - gamma-Butyrolactone

Local:
Gamma-Butyrolactone is an intermediate for the manufacture of butyric acid compounds and pyrrolidones used as a plasticizer, solvent for polymers, nylon precursor and in insecticides. GBL is used as a solvent for surface treatment for textiles and metal coated plastics; polymers (ABS, PVC, polyvinylcarbazole, PS, nylons and cellulose acetate ); paint remover; petroleum industry for natural gas, acetylene, paraffins, and naphthene separations; viscosity modifier and curing agent for polyurethanes. GBL is also used in photochemical etching and vitamin and pharmaceutical preparations.

GENERAL DESCRIPTION OF LACTONE:

Lactone, Lactam, Lactim

Lactone is an internal cyclic monoester (anhydride) derived from the hydroxyl and carboxyl radicals of gamma or delta hydroxy acids by the removal of a H2O between a carboxyl and a hydroxyl group in the same molecule; gamma-hydroxybutyric acid forms gamma-butyrolactone and delta-hydroxydecanoic acid forms delta-decalactone spontaneously. In result, prefixes describe the ring size: beta- is for 4-membered ring), gamma- , 5-membered, and delta-, 6-membered ring. Lactam (a cyclic amide) is the nitrogen analog of lactone. Gamma-aminobutyric acid forms gamma-butyrolactam (also called 2-pyrrolidinone). Lactim is the tautomeric enol form of lactam. Lactam structure, a heteroatomic cyclic amide compound, is an important part in antibiotics such as penicillin. These structures, cyclic esters and analogues, are active nucleuses in pharmacological activity and flavorings. Their good solvency properties also useful in industrial application. Lactams have big demand in artificial fibre industry. They are polymerizable and used as nylon precursors.

SALES SPECIFICATION

APPEARANCE

clear liquid
ASSAY

99.5% min

COLOR, HAZEN

10 max

MOISTURE

0.2% max

TRANSPORTATION
PACKING 200kgs in drum
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Serious eye damage. Specific target organ toxicity - single exposure. Hazard statements: Harmful if swallowed. Causes serious eye damage. May cause drowsiness or dizziness.

GHS

 

SIGNAL WORD

Danger

PICTOGRAMS

PICTOGRAM_GHS07_exclamation.jpgPICTOGRAM_GHS05_corrosion.jpg

HAZARD STATEMENTS

H302-H318-H336

P STATEMENTS

P261-P280-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

CODE_Xn_Xi_harmful_Irritant.gif

RISK PHRASES

22-41-67

SAFETY PHRASES

26-39

 

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