ASPARTAME

PRODUCT IDENTIFICATION
CAS NO. 22839-47-0

ASPARTAME
EINECS NO. 245-261-3

H.S. CODE

 2924.29.9500
MOL WT. 294.31
FORMULA HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3

TOXICITY

 Oral rat LD50: >10 gm/kg
SYNONYMS N-L-alpha-Aspartyl-L-phenylalanine 1-methyl ester; Equal;
1-Methyl N-L-alpha-aspartyl-L-phenylalanate; 1-Methyl N-L-alpha-aspartyl-L-phenylalanine; 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester; 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid; Asp-phe-ome; Aspartam; Aspartame; L,L-alpha-Aspartame; Aspartamo; Aspartamum; Aspartylphenylalanine methyl ester; Canderel; Dipeptide sweetener; L-Aspartyl-L-phenylalanine methyl ester; Methyl L-alpha-aspartyl-L-phenylalanate; Methyl L-aspartyl-L-phenylalanine; Methyl N-L-alpha-aspartyl-L-phenylalaninate; Methyl aspartylphenylalanate; Other RN: 172964-81-7, 53906-69-7, 7421-84-3
SMILES C([C@@H](NC([C@@H](CC(O)=O)N)=O)C(OC)=O)c1ccccc1

CLASSIFICATION

Peptides / Sweeteners / Flavoring Agent

EXTRA NOTES

 Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.
Sweetness: Sucrose X 160 ~ 200

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white odorless crystalline powder
MELTING POINT 248 - 250 C
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER slightly soluble
pH 5.3 (8% sol.)
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Aspartame

PubChem Compound Summary - Aspartame

IPCS INCHEM -  Aspartame

Drug Bank -  Aspartame

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Aspartame

http://www.ebi.ac.uk/ -  Aspartame

http://www.ncbi.nlm.nih.gov/ -  Aspartame

Human Metabolome Database - Aspartame

Material Safety Data Sheet

http://www.fsai.ie/
Aspartame (E951) has been used as a sweetener in foods and as a table-top sweetener for more than 20 years in many countries throughout the world. Aspartame is the methyl ester of the dipeptide of two amino acids, phenylalanine and aspartic acid. It is an odourless, white crystalline powder which has a clean, sweet taste. It is referred to as an intense (or artificial) sweetener and is used to replace sugar in a wide range of sugar-free and low-calorie foods. It has the same calorific value as sugar, but is about 200 times sweeter than sugar and so only a small amount is needed to sweeten products. Aspartame is sometimes referred to under its original trade name of ˇ°Nutrasweetˇ±.

Local:
Peptides are the members of the compounds composed of two or more amino acids joined by the linking between one amino acid residue and the carboxyl group of the next amino acid by hydrolysis into linear, branched or cyclical structures. The link is an amide bond, and is sometimes referred to as a peptide bond. Peptides are playing a promising role in the molecular biology and in the creating medicines. Peptides are used in the study of protein structure and function, antibodies for the inhibition of cancer, for the study of protein structure and function research. Peptides are also used as instrumental in mass spectrometry. Biological activities of peptide are applicable in the fields of nutrition, medicine, and cosmetics.

  • Dipeptide: a molecule consisting of two amino acids
  • Tripeptide a molecule consisting of three amino acids
  • Octapeptide: a molecule consisting of eight amino acids
  • Oligopeptide: a polypeptide composed of approximately 2-12 amino acids length (or 3 to 40 component amino acids)
  • Polypeptide: a single molecule composed of approximately 13 or more amino acids.
  • Protein: a linear polypeptides that are normally synthesized on ribosomes.

Aspartame (or Aspartylphenylalanine) is the methyl ester of the dipeptide aspartyl phenylalanine. Chemically, it is Succinamic acid, 3-amino-N-(alpha- carboxyphenethyl)-, N-methyl ester, stereoisomer.  Aspartame is prepared by components of amino acids, aspartic acid and phenylalanine, with a small amount of methanol. It's marketed names are NutraSweet, Equal, Egal, or Canderal. Aspartame is a low-calorie sweetener used to sweeten a variety of foods and beverages, and as a tabletop sweetener. Aspartame is about 150-200 times as sweet as sucrose, tastes good, enhances flavors, saves calories and does not contribute to tooth decay. it is now the most popular sweetening ingredient in diet soft drinks. Aspartame trends to separate components when heated or over long periods, resulting in a loss of sweetness.

ARTIFICIAL SWEETENERS
  • Acesulfame potassium
  • Alitame
  • Aspartame
  • N-Phenylacetyl-Gly-Lys
  • Cyclamate
  • Dulcin
  • Neohesperidine dihydrochalcone
  • Neotame
  • 5-Nitro-2-propoxyaniline
  • Saccharin
  • Sucralose
SALES SPECIFICATION

BIBLIOGRAPHY

FCC IV / USP23

APPEARANCE

White crystalline powder or Granule
ASSAY (on Dry Basis)

98.0~101.0%
LOSS ON DRYING

4.5% max  (105°C, 4 hours)

RESIDUE ON IGNITION

0.2% max
HEAVY METALS

10ppm  max
pH

4.5 ~ 6.5

OPTICAL ISOMERS

0.04% max
ARSENIC (as As)

3ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

Not known
EC DIRECTIVES

 
HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 22-24/25
PRICE INFORMATION