CYANOCOBALAMIN

PRODUCT IDENTIFICATION
CAS NO. 68-19-9

CYANOCOBALAMIN 

EINECS NO. 200-680-0
FORMULA C63H88CoN14O14P
MOL WT. 1355.38

H.S. CODE

 2936.26

TOXICITY

  
SMILES

 

CLASSIFICATION

VITAMINS /
SYNONYMS Vitamin B12; CN-Cbl; Anacobin;
alpha-(5,6-Dimethylbenzimidazolyl)cyanocobamide; Cyanocob (III) alamin; Dimethylbenzimidazoylcobamide; Co(alpha)-[(alpha)- (5,6-Dimethylbenzimidazolyl)]- Co(beta)- cyanocobamide;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE red crystalline powder
MELTING POINT 300 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Moderately soluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

AUTOIGNITION

 

FLASH POINT

 > 110 C
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Cobalamin [cobal(t) + (vit)amin] is a compound containing the substituted corrin ring (polyaromatic ring consisting of 4 pyrrole subunits which are joined by methylene links on opposite sides and the two of the pyrroles are joined directly) and 5,6-dimethylbenzimidazole, as the aglycon attached by a glycosyl link. Vitamin B12 is a cyanide ion substituted cobalamin derivative (cyanocobalamin) with the presence of cobalt mineral at 6 position. Vitamin B12 is the only vitamin which contains metal ion (trivalent cobalt). Cobalamin is sometimes defined as the synonym of Vitamin B12, although they are not same compound but closely related compounds to fulfill folic acid role. Vitamin B12 is typically any substituted cobalamin derivative having similar biological activity. Hydroxocobalamin (abbreviated OHCbl), a cobalamin derivative in which the substituent is a hydroxyl group, is called vitamin B12b. Methylcobalamin (abbreviated MeCbl) is a cobalamin derivative in which the substituent is a methyl group.  MeCbl is involved in several biosynthesis including methionine. Adenosylcobalamin (abbreviated AdoCbl)is a cobalamin derivative in which the substituent is deoxyadenosyl. MeCbl and AdoCbl are two metabolically active coenzyme forms synthesized upon ingestion of vitamin B12 and are the predominant form in the liver and in the serum respectively. Vitamin B12 is a water-soluble hematopoietic vitamin. It is needed in various body processes including the manufacture and the maintenance of red blood cells, the synthesis of DNA, the stimulate of nerve cells, the growth promotion and energy release. Vitamin B12 is the antipernicious anemia factor and essential for normal hemopoiesis. It is used to treat the absence of intrinsic factor which is responsible for the absorption of B12 from the intestine; including particularly pernicious anemia and other megaloblastic anemias and associated neuropathy. Vitamin B12 is administered subcutaneously, intramuscularly, or orally.

Molecular compounds of cobalamin

Product

CAS RN
Cyanocobalamin 68-19-9
Transcobalamin III 12634-50-3
Transcobalamin I 12651-27-3
Transcobalamin II 12651-28-4
Cyanocobalamin Co 57 13115-03-2
Cobalamin 13408-78-1
2-Methyl-2-aminopropanol-B12 13408-80-5
Hydroxocobalamin 13422-51-0
Mecobalamin 13422-55-4
Aquacobalamin 13422-52-1
Cyanocobalamin Co 60 13422-53-2
Cobinamide 13497-85-3
Cobamamide 13870-90-1
Vitamin B12 factor B 13963-62-7
2',5'-Dideoxyadenosylcobalamin 14220-72-5
cob(II)alamin 14463-33-3
(Carboxymethyl)cobalamin 14517-61-4
Cobyric acid 14708-92-0
5-Hydroxybenzimidazolylcobamide 14708-95-3
Cobamide 14709-02-5
Dicyanocobalamin 15041-09-5
Chlorocobalamin 15041-07-3
Sulfitocobalamin 15671-27-9
Cyanocobalamin Co 58 18195-32-9
Nitritocobalamin 20623-13-6
Acetatocobalamin 22465-48-1
Cyanocobalamin-e-monocarboxylic acid 26264-28-8
Cyanocobalaminetricarboxylic acid 26319-38-0
Cyanocobalaminemonocarboxylic acid 26403-50-9
Cyano-N-methyl-cobalamin 26969-91-5
Aquochlorocobalamin 27085-12-7
Vitamin B12 anilide 27099-83-8
Cobinamide dicyanide 27792-36-5
Cobyrinic acid 33593-50-9
Cyanocobalamin-b-monocarboxylic acid 38218-77-8
Cobamamide 5'-phosphate 39044-48-9
Cyanocobalaminedicarboxylic acid 39390-27-7
Formylmethylcobalamin 41871-63-0
Aquocobalamin acetate 49552-79-6
1,N(6)-Ethenoadenosylcobalamin 54635-00-6
Cobyrinic acid hexamethyl ester f-nitrile 56456-66-7
Methylcobalamine chlorpalladate 58220-71-6
Hydroxocobalamin hydrochloride 58288-50-9
Adeninylethylcobalamin 59209-78-8
Hydroxocobalamin monohydrochloride 59461-30-2
Cysteinylcobalamin 60659-91-8
Ferribalamin 69743-59-5
Aminopropylcobalamin 72728-11-1
Proheparum 72980-85-9
Triredisol 76773-81-4
Vitamin B12a 78091-12-0
Thiobanzyme 79028-53-8
(2-Hydroxy-5,6-dimethylbenzimidazolyl)cobamide 90654-05-0
(2-Amino-5,6-dimethylbenzimidazolyl)cobamide 90654-06-1
2-Methylsulfonyladenylcobamide 107672-06-0
2-Methylsulfinyladenylcobamide 107688-04-0
4-Cresolylcobamide 119637-75-1
Phenolyl cobamide 125939-05-1
Glutathionylcobalamin 129128-04-7
Coalpha-(alpha-5,6-dimethylbenzimidazolyl)-cobeta-cyanocobamide 143481-69-0
Adenosylcobinamide methyl phosphate 147736-07-0
SALES SPECIFICATION
USP 24

APPEARANCE

 red crystalline powder

CONTENT

 96.0% - 100.5%
IDENTIFICATION Pass
LOSS ON DRYING

12.0% max
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION

Vitamin B is a group of water-soluble vitamins that include thiamine (vitamin B1), riboflavin (vitamin B2), riboflavin 5'- phosphate, nicotinic acid, Vitamin B6 Group (Pyridoxine, pyridoxal, pyridoxamine), panthothenic acid (vitamin B3 or vitamin B5), inositol, p-aminobenzoic acid, biotin (vitamin B7), folic acid (vitamin B9), and vitamin B12 (cobalamins)