DIPOTASSIUM GLYCYRRHIZINATE

PRODUCT IDENTIFICATION

CAS NO. 68797-35-3

DIPOTASSIUM GLYCYRRHIZINATE

EINECS NO. 272-296-1
FORMULA C42H62O16·2K
MOL WT. 901.12

H.S. CODE

TOXICITY

SMILES

 

CLASSIFICATION

 

SYNONYMS Glycyrrhizic acid Dipotassium salt;
(3-beta,20-beta)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D- glucopyranuronosyl- alpha-D-glucopyranosiduronic acid, dipotassium salt;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH 5 - 6 (1% sol.)
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Three varieties of the species have been reported; Spanish licorice and Italian licorice are assigned to G. glabra var. typica, Russian licorice is G. glabra var. glandulifera, and Persian and Turkish licorices are G. glabra var. violacea. About 90 kinds of phenolic compounds have been isolated from the plants. About 50 of them are substituted with isoprenoid group(s), e.g., 3-methyl-2-butenyl (prenyl) group, 2,2-dimethylpyran ring, etc. These G. glabra could be classified into two groups with the constituents of isoprenoid-substituted flavonoids. Type I licorice is Spanish and Russian licorices. The main isoprenoid-substituted flavonoid of the plants is a pyranoisoflavan, glabridin. The 5-position of most flavonoids from the type I plants is unsubstituted, glabrene, glabrol, 3-hydroxyglabrol. Type II licorice is Chinese and Kyrghiz G. glabra. From these plants, both 5-unsubstituted flavonoids and 5-oxygenated flavonoids (e.g., 3',8-diprenylated dalbergioidin, have been isolated. Nevertheless, most flavonoids from these plants are 5-hydroxy- or 5-methoxy-flavonoids. (http://www.iupac.org/)

Glycyrrhizin, one of the main components found in licorice, is believed to contribute to the herb's healing properties. Laboratory studies have reported that glycyrrhizin reduces inflammation, promotes secretion of mucous (usually through coughing), soothes irritation, protects the stomach and gastrointestinal tract, and stimulates the activity of the adrenal glands (regulates cortisol, the stress hormone). ( http://www.umm.edu/)

Glycyrrhiza (the dried rhizome and roots of various species of Glycyrrhiza) contains triterpene glycoside called Glycyrrhizin, Glycyrrhizic acid, or Glycyrrhizinic acid (salts are called Glycyrrhizin) which is converted to glycyrrhetinic acid (the aglycone) and two moles of gucuronic acid (the glycone) on hydrolysis. Glycyrrhizinic acid is potentially 50 times sweeter than sucrose. Licorice (liquorice in British spelling) is the alteration of Glycyrrhiza glabra, a Mediterranean perennial plant with blue pealike blossoms. Glycyrrhiza is the active principle for sweetening, flavoring and pharmaceutical applications. It is effective in treatment of peptic ulcer. It is used in brewing and for confectionery and tobacco flavorings. It is frequently used in medicines to mask the unpleasant flavours. It has been used medicinally for highly effective coughs and as a mild laxative. It promotes the ejection of mucus or exudate from the lungs, bronchi, and trachea; sometimes extended to antitussives. Glycyrrhetinic acid has corticosteroid-like structure, thus is useful as an anti-inflammatory and co-emulsifier to treat skin disorders and in cosmetics.

Pharmacological actions:

  • Anti-Inflammatory
  • Antiallergic
  • Antibacterial
  • Antiviral

Glabridin (the main isoflavan compound in fraction of licorice extract), and glabrene ( the main isoflavene) demonstrats significant antioxidant and estrogen-like activities. Some data suggest that they protect low-density lipoprotein against lipid peroxidation.

SALES SPECIFICATION

APPEARANCE

white crystalline powder
CONTENT

95.0% min (Anhydrous basis)

LOSS ON DRYING

5.0% max

ARSENIC

3ppm max

HEAVY METALS

10ppm max

RESIDUE ON IGNITION

18.0 - 21.0%

RELATED SUBSTANCE 2.0% max
TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-24/25



PRICE INFORMATION

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