METHYLCOBALAMIN HYDRATE

PRODUCT IDENTIFICATION
CAS NO. 13422-55-4

METHYLCOBALAMIN HYDRATE 

EINECS NO.
FORMULA C63H91CoN13O14P
MOL WT. 1344.38

H.S. CODE

TOXICITY
SMILES

 

CLASSIFICATION

 
SYNONYMS Methyl B12; Mecobalamin;
alpha-(5,6-Dimethylbenzimidazolyl) methylcobamide; MeCbl; Co(alpha)-[(alpha)-(5,6-Dimethylbenzimidazolyl)]- Co(beta)-methylcobamide;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE red crystalline powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Moderately soluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

AUTOIGNITION

 

FLASH POINT

  
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Cobalamin [cobal(t) + (vit)amin] is a compound containing the substituted corrin ring (polyaromatic ring consisting of 4 pyrrole subunits which are joined by methylene links on opposite sides and the two of the pyrroles are joined directly) and 5,6-dimethylbenzimidazole, as the aglycon attached by a glycosyl link. Vitamin B12 is a cyanide ion substituted cobalamin derivative (cyanocobalamin) with the presence of cobalt mineral at 6 position. Vitamin B12 is the only vitamin which contains metal ion (trivalent cobalt). Cobalamin is sometimes defined as the synonym of Vitamin B12, although they are not same compound but closely related compounds to fulfill folic acid role. Vitamin B12 is typically any substituted cobalamin derivative having similar biological activity. Hydroxocobalamin (abbreviated OHCbl), a cobalamin derivative in which the substituent is a hydroxyl group, is called vitamin B12b. Methylcobalamin (abbreviated MeCbl) is a cobalamin derivative in which the substituent is a methyl group.  MeCbl is involved in several biosynthesis including methionine. Adenosylcobalamin (abbreviated AdoCbl)is a cobalamin derivative in which the substituent is deoxyadenosyl. MeCbl and AdoCbl are two metabolically active coenzyme forms synthesized upon ingestion of vitamin B12 and are the predominant form in the liver and in the serum respectively. Vitamin B12 is a water-soluble hematopoietic vitamin. It is needed in various body processes including the manufacture and the maintenance of red blood cells, the synthesis of DNA, the stimulate of nerve cells, the growth promotion and energy release. Vitamin B12 is the antipernicious anemia factor and essential for normal hemopoiesis. It is used to treat the absence of intrinsic factor which is responsible for the absorption of B12 from the intestine; including particularly pernicious anemia and other megaloblastic anemias and associated neuropathy. Vitamin B12 is administered subcutaneously, intramuscularly, or orally.
SALES SPECIFICATION

APPEARANCE

 red crystalline powder

CONTENT

 96.0% - 100.5%
IDENTIFICATION

Infrared absorption (conforms to USP)
Ultraviolet absorption (conforms to USP)

LOSS ON DRYING

6.0% max

SOLVENT RESIDUE

0.5% max

RELATED IMPURITY

2.0% max
ACID IMPURITY

3.0% max
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION

Vitamin B is a group of water-soluble vitamins that include thiamine (vitamin B1), riboflavin (vitamin B2), riboflavin 5'- phosphate, nicotinic acid, Vitamin B6 Group (Pyridoxine, pyridoxal, pyridoxamine), panthothenic acid (vitamin B3 or vitamin B5), inositol, p-aminobenzoic acid, biotin (vitamin B7), folic acid (vitamin B9), and vitamin B12 (cobalamins)