RIBOFLAVIN
|
PRODUCT
IDENTIFICATION
|
CAS
NO. |
83-88-5
|
|
EINECS
NO. |
201-507-1 |
FORMULA |
C17H20N4O6 |
MOL
WT. |
376.37 |
H.S.
CODE
|
2936.23.0000 |
TOXICITY
|
Oral Rat LD50: > 10gm/kg |
SYNONYMS |
7,8-Dimethyl-10-ribitylisoalloxazine; |
3,10-Dihydro-7,8-dimetyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]
benzo[g]pteridine-2,4-dione; Ovoflavin; Zinvit-G;
Riboflavin; Lactoflavin; Vitamin B2;
6,7-Dimethyl-9-D-ribitylisoalloxazine, 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine;
7,8-Dimethyl-10-ribitylisoalloxazine; Aqua-Flave; Beflavin;
Beflavine; 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-
benzo(g) pteridine-2,4(3H,10H)-dione; 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo(g)pteridin-
10(2H)-yl)-D-ribitol;
Dermadram; Fiboflavin; Flavaxin; Flavin BB; Flaxain; Hyflavin;
7,8-Dimethyl-10- (D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine;
7,8-Dimethyl-10-D-ribitylisoalloxazine; Lactobene; Lactoflavin;
Lactoflavine; Ribipca; Ribocrisina; Riboderm; Riboflavin; Riboflavina;
Riboflavine; Riboflavinequinone; Riboflavinum; Ribosyn; Ribotone;
Ribovel; Russupteridine Yellow III; Vitaflavine; Vitamin B2
; Vitamin Bi; Vitamin G; Vitasan B2; Other RN: 130609-39-1,
535950-32-4. 890044-91-4 |
SMILES |
n1(c2c(nc3c1nc(=O)[nH]c3=O)cc(C)c(c2)C)C[C@H]([C@H]
([C@H](CO)O)O)O |
CLASSIFICATION
|
Natural
Colorant, Vitamins,
Dermatologic agent, Photosensitizing agent, Radiation-Sensitizing
agent, Enzyme co-factor
|
CLASSIFICATION
|
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and
leafy vegetables. The richest natural source is yeast. It occurs in the free
form only in the retina of the eye, in whey, and in urine; its principal forms
in tissues and cells are as Flavin mononucleotide and Flavin-adenine
dinucleotide. |
PHYSICAL AND CHEMICAL PROPERTIES
|
PHYSICAL
STATE |
yellow to orange
crystalline powder |
MELTING POINT |
280
- 290 C (Decomposes) |
BOILING
POINT |
|
SPECIFIC GRAVITY |
|
SOLUBILITY
IN WATER |
Slightly
soluble
|
SOLVENT
SOLUBILITY
|
Soluble
in dilute alkaline solutions, insoluble in alcohol
|
VAPOR DENSITY |
|
pKa |
10.2
(Dissociation Constant
at 25 C) |
log P |
-1.46E+00
(Octanol-water) |
VAPOR
PRESSURE |
8.92E-22 (mmHg at 25 C) |
HENRY LAW
CONSTANT |
3.59E-19 (atm-m3/mole at 25 C) |
OH RATE
CONSTANT |
2.47E-10 (cm3/molecule-sec
at 25 C Atmospheric) |
AUTOIGNITION
|
|
NFPA
RATINGS
|
Health hazard: 0, Fire: 0, Reactivity Hazard: 0
|
REFRACTIVE
INDEX
|
|
FLASH
POINT |
|
STABILITY |
Stable
under ordinary conditions. Light sensitive. |
EXTERNAL LINKS
& GENERAL
DESCRIPTION
|
Wikipedia
Linking
Google
Scholar Search
Drug
Information Portal (U.S. National Library of Medicine) - Riboflavin
http://www.idpas.org/ Riboflavin
deficiency should be considered a possible risk factor
for preeclampsia. Insufficient concentrations of the
riboflavin-derived cofactors flavin adenine dinucleotide
and flavin adenine mononucleotide could contribute to
the established pathophysiologic changes including mitochondrial
dysfunction, enhanced oxidative stress, and disturbances
in nitric oxide release.
http://www.eatright.org/ You have heard of the many vitamins and minerals our body needs to stay
healthy, but you may not know specifically what they do for you. For example, you may know you need thiamin, riboflavin and niacin, but do you
know why you need each of them?
- Thiamin helps produce energy from carbohydrates in all cells of your body.
Thiamin can be found in whole-grain and enriched grain products such as bread,
rice, pasta and tortillas.
- Riboflavin helps produce energy in all cells of your body and change an
amino acid called tryptophan in your food into niacin. Riboflavin is found in
milk and other dairy foods, enriched breads. Eggs, green, leafy vegetables and
nuts provide smaller amounts.
- Niacin helps your body use sugars and fatty acids, helps enzymes function
normally in your body and helps produce energy. Foods high in protein are
usually good sources of niacin such as poultry, fish, beef, peanut butter and
legumes.
Consult a registered dietitian to find out how much of each vitamin is right
for you. Remember, a variety of foods with plenty of vitamins and minerals is
part of your ticket to good health.
Local: Riboflavin: A member of the vitamin B complex (water-soluble) including thiamine (vitamin B1), riboflavin (vitamin
B2), riboflavin 5'-
phosphate, nicotinic acid, Vitamin B6 Group (Pyridoxine,
pyridoxal, pyridoxamine), panthothenic acid (vitamin B3
or vitamin B5), inositol,
p-aminobenzoic acid, biotin (vitamin B7), folic acid (vitamin
B9), and vitamin
B12
(cobalamins). Riboflavin
is a water-soluble yellow to orange
fluorescent pigment with the chemical structure of substituted isoalloxazine
ring system linked to ribitol. (Flavin is a water-soluble compound containing
the isoalloxazine nucleus which is characterized by a yellow color and intense
green fluorescence when oxidized. Ribitol is a sugar alcohol formed by reduction
of the carbonyl group of ribose). Riboflavin is essential to human nutrition as
a component of two coenzymes; flavin mononucleotide (FMN) and flavin adenine
dinucleotide (FAD) of flavoproteins, that are associated with several
respiratory enzymes in plants and animals as electron carriers, important in
biochemical oxidations and reductions. The deficiency of riboflavin results in
the disease beriberi. The phosphoric acid esters of riboflavin are administered
orally or parenterally in the treatment of dietary riboflavin
deficiency.
- Riboflavin 5'-Phosphate (Flavin Mononucleotide, FMN): serving as
an electron carrier in biochemical oxidations and reductions; acting as a
coenzyme for a number of oxidative enzymes, including NADH
dehydrogenase.
- Riboflavin 5'-Phosphate sodium: the sodium salt of riboflavin
5'-phosphate; administered orally or parenterally in the treatment of dietary
riboflavin deficiency.
- Riboflavine 5'-Adenosine Diphosphate (Flavin Adenine
Dinucleotide. FAD): serving as an electron carrier in biochemical oxidations and
reductions; forming prosthetic group of many flavoprotein enzymes, including
D-amino acid oxidase and xanthine oxidase; a coenzyme composed of riboflavin
5'-phosphate (FMN) and adenosine 5'-phosphate linked by a pyrophosphate bond.
- Flavin Adenine Dinucleotide Sodium: the sodium salt of Riboflavine
5'-Adenosine Diphosphate ; administered orally or parenterally in the treatment
of dietary riboflavin deficiency.
|
SALES
SPECIFICATION |
BIBLIOGRAPHY
|
USP23
/ BP93
|
APPEARANCE
|
yellow to orange
crystalline powder |
IDENTIFICATION
|
Complies
(Test A, B)
|
ASSAY
|
98.0 ~102.0% |
OPTICAL
ROTATION
|
+56.5°
~ +59.5°
|
LOSS
ON DRYING
|
1.5%
max |
RESIDUE
ON IGNITION
|
0.2%
max
|
IMPURITY
|
Complies
|
TRANSPORTATION |
PACKING |
25kgs
in Fiber Drum |
HAZARD CLASS |
Not regulated |
UN
NO. |
|
PRICE
INFORMATION |
|