THIAMINE HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 67-03-8

THIAMINE HYDROCHLORIDE

EINECS NO. 200-641-8
FORMULA C12H17ClN4OS·HCl
MOL WT. 337.27

H.S. CODE

 2936.22

TOXICITY

 
SYNONYMS Vitamin B1 Hydrochloride; Thiavit; Timidon; Tiaminal;
Clotiamina; Metabolin; Thiadoxine; Vitaneuron; Thiamine hydrochloride; Aneurine Hydrochloride; Tiamina, clorhidrato; Thiamine, chlorhydrate;
SMILES

 

CLASSIFICATION

VITAMINS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE Almost White, granular powder
MELTING POINT 260 C
BOILING POINT

 

SPECIFIC GRAVITY

1.4

SOLUBILITY IN WATER 100 g/100 ml
pH 2.7-3.4 (at 10 g/l)
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

100 C

STABILITY Stable under ordinary conditions

APPLICATIONS
Thiamine: A member of the vitamin B complex (water-soluble) including thiamine (vitamin B1), riboflavin (vitamin B2), riboflavin 5'- phosphate, nicotinic acid, Vitamin B6 Group (Pyridoxine, pyridoxal, pyridoxamine), panthothenic acid (vitamin B3 or vitamin B5), inositol, p-aminobenzoic acid, biotin (vitamin B7), folic acid (vitamin B9), and vitamin B12 (cobalamins). Thiamine has the structure of substituted-pyrimidine linked to substituted-thiazole. Thiamine is an essential ingredient for the biosynthesis of the coenzyme thiamine pyrophosphate which plays an important role in carbohydrate metabolism (catalyzing decarboxylation of various alpha-keto acids). Thiamine hydrochloride form is generally employed. This vitamin is a factor for appetite, normal intestinal function, cardiovascular and nervous systems.
  • Thiamine Hydrochloride: Hydrochloride salt form of thiamine; white, hygroscopic crystals;  soluble in water, insoluble in ether, decomposes at 247 C; the form in which thiamine is generally employed for the prophylaxis and treatment of thiamine deficiency states orally and intramuscularly.
  • Thiamine Mononitrate: Nitrate salt form of thiamine for the preparation of various multivitamins.
  • Thiamine Pyrophosphate: The coenzyme in a variety of reactions or prosthetic component of carboxylase.

Molecular compounds of thiamine

Product

CAS RN
Prosultiamine 59-58-5
Thiamine 59-43-8
Thiamine hydrochloride 67-03-8
Thiamine disulfide 67-16-3
Thiamine pyrophosphate 136-09-4
Oxythiamine 136-16-3
Thiamine thiazole 137-00-8
Cetotiamine 137-76-8
Cocarboxylase 154-87-0
Acetiamine 299-89-8
Bentiamine 299-88-7
Imidazolethiamine 305-25-9
Thiamine thiazolone 490-82-4
Monophosphothiamine 532-40-1
Thiamine mononitrate 532-43-4
Pyrithiamine 534-64-5
Allithiamine 554-44-9
Oxythiamine 582-36-5
Oxythiamine chloride hydrochloride 614-05-1
S-Carbethoxythiamine hydrochloride 616-97-7
Dicethiamine hydrochloride 616-96-6
Thiamine phosphate dihydrogen phosphate salt 635-97-2
Fursultiamine 804-30-8
Prosultiamine hydrochloride 973-99-9
Thiamine disulfide phosphate 992-46-1
Chlormethiazole ethanedisulfonate 1867-58-9
O-Benzoylthiamine 1948-58-9
O,S-Dibenzoyl thiamine hydrochloride 2105-44-4
Thiamine tetrahydrofurfuryl disulfide hydrochloride 2105-43-3
Bisbentiamine 2667-89-2
Sulbutiamine 3286-46-2
Acetylthiamine 3419-28-1
Thiamine triphosphate 3475-65-8
Cycotiamine 6092-18-8
Thiamine bromide 7019-71-8
Beclotiamine 13471-78-8
Tetrahydrothiamine 15233-41-7
Dimethialium 15659-74-2
Thiamine phophate hydrochloride dihydrate 16028-14-1
Bisbutitiamine 18481-23-7
Thiamine disulfide hydrochloride 18642-10-9
2-(1-Hydroxyethyl)thiamine pyrophosphate 20319-27-1
Antithiamine factor 20733-94-2
Thiamine monophosphate bis(glucosamine) 20936-20-3
Thiamine nicotinate monohydrochloride 21946-31-6
Benfotiamine 22457-89-2
Thiamine diphosphate hydrochloride 23883-45-6
Acetiamine hydrochloride 28008-04-0
S-(beta-Propiophenone)thiamine 28568-54-9
Methylthioethylthiamine 33071-34-0
Methylsulfinylethylthiamine 33071-33-9
Tetrahydrothiamine pyrophosphate 35728-83-7
Thiamine disulfide monotheophyllinate 36410-91-0
S-(beta-p-Methylpropiophenone)thiamine 42207-96-5
S-(beta-p-Methoxypropiophenone)thiamine 42207-95-4
S-(beta-p-Chloropropiophenone)thiamine hydrochloride 42282-42-8
Methylsulfinylethylthiamine disulfide 49575-13-5
Hydroxyethylthiamine 51230-37-6
Homothiamineglycol 53855-90-6
Bisbutyl thiamine 54690-41-4
Thiamine thiothiazolone pyrophosphate 59733-98-1
Thiamine thiazolone pyrophosphate 59733-97-0
Thiooratin 59785-18-1
Tetrahydrothiamine monophosphate 60689-64-7
Thiooratin 61227-05-2
2-(alpha-Hydroxybenzyl)thiamine chloride 62324-27-0
Ethenothiamin 74636-68-3
4-Azido-2-nitrobenzoylthiamine 78897-57-1
2-Carbamoylphenyl thiamine monophosphate 79929-28-5
3-(2,2-Dichlorodiethyl)aminopropionic acid oxythiamine ester 81575-46-4
alpha-Lactylthiamine 82205-83-2
Thiamine indole-3-propionate 83661-65-8
Oxythiamine hexyl disulfide 84714-58-9
Oxythiamine octyl disulfide 84714-60-3
Oxythiamine nonyl disulfide 84714-61-4
Oxythiamine heptyl disulfide 84714-59-0
Oxythiamine amyl disulfide 84714-57-8
3,3-Dimethyl-1-phenyl-1-phthalylacetic acid oxythiamine ester 99447-45-7
2-Acetylthiamine pyrophosphate 104114-88-7
Oxythiamine bromide monohydrobromide 108051-45-2
O-Bromoacetylthiamine 117826-71-8
Oxythiamine disulfide monosulfoxide 129228-57-5
Oxythiamine disulfide 134028-70-9
Oxythiamine disulfide nicotinate 144722-72-5
SALES SPECIFICATION

BIBLIOGRAPHY

USP23 / BP93

APPEARANCE

 white crystal powder

IDENTIFICATION

Passes Test

ASSAY

 98.0 ~102.0%
ACIDITY OR ALKALINITY 2.7 ~ 3.4

LOSS ON DRYING
1.0% max
CLARITY   OF SOLUTION

Passes Test

HEAVY METALS

20ppm max

SULPHATED ASH

0.2% max

WATER

5.0% max

NITRATE

Absence
TRANSPORTATION
PACKING
25kgs in Fiber Drum
HAZARD CLASS Not regulated
UN NO.  

GENERAL DESCRIPTION OF VITAMIN B

A group of water-soluble vitamins that include thiamine (vitamin B1), riboflavin (vitamin B2), riboflavin 5'- phosphate, nicotinic acid, Vitamin B6 Group (Pyridoxine, pyridoxal, pyridoxamine), panthothenic acid (vitamin B3 or vitamin B5), inositol, p-aminobenzoic acid, biotin (vitamin B7), folic acid (vitamin B9), and vitamin B12 (cobalamins)