1,3,5-TRIMETHOXYBENZENE

PRODUCT IDENTIFICATION
CAS NO. 621-23-8

1,3,5-TRIMETHOXYBENZENE

EINECS NO. 210-673-4
FORMULA C6H3(OCH3)3
MOL WT. 168.19

H.S. CODE

  

TOXICITY

  
SYNONYMS Phloroglucinol trimethyl ether; Sym-Trimethoxybenzene;
O,O,O-1,3,5-trimethylresorcinol; O,O,O-1,3,5-Trimethylresorcin (German); O,O,O-1,3,5-Trimetilresorcinol (Spanish); O,O,O-1,3,5-Triméthylresorcinol (French);
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystal
MELTING POINT 51 - 53 C
BOILING POINT

255 C

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 Health: 1; Flammability: 1; Reactivity: 0

AUTOIGNITION

 

FLASH POINT

112 C

STABILITY Stable under normal conditions, light and air sensitive

APPLICATIONS
There are three isomeric compounds of trihydroxybenzene molecule structure, which all have traditional names respectively. Their names are related with the equivalent dihydroxybenzene compounds. The names of the three compounds indicate which of the hydrogens on the benzene ring portion of the molecule have been replaced by hydroxyl groups. The isomer of 1,2,3-trihydroxybenzene is called pyrogallic acid (or pyrogallol).  This compound is a poisonous acid, derived from gallic acid, and used  in the manufacturing colorants such as azo dyes and photographic developers and externally as an antimicrobial to treat certain skin diseases. Phloroglucin (or called phloroglucinol) is 1,3,5-trihydroxybenzene which presents as the genin of many glycosides, particulrally in the bark of apple and other trees. It is used in as a reagent for pentoses, pentosans, glycuronates, hydrochloric acid in gastric juice. It is an excellent bone decalcifying agent and a floral preservative. It is used in the manufacture of pharmaceuticals. The 1,2,4- isomer is hydroxyquinol (or called hydroxyhydroquinone). Trihydroxybenzenes have three hydroxyl groups in one benzene ring. They can derive numerous esters and salts. They are used as chemical intermediate to synthesis target molecules of pharmaceuticals, pesticides, stabilizer, antioxidant, colorants, perfumes, photoinitiators, and other organic compounds. Methoxylated phenol family compounds have bacteriostatic and  floral preservative properties.  They are used in pharmaceuticals and flavorings. They are used in formulating insect attractants, analgesics, biocides and antiseptics. They are also used in manufacturing stabilizers, antioxidants, and UV absorbers for plastics and rubbers.  An example of target product from 1,3,5-Trimethoxybenzene is buflomedil, a vasoactive agent which improves the symptoms of impaired blood circulation.

Members of phloroglucinol molecules

Product

CAS RN
2,4,6-Trihydroxybenzoic acid 83-30-7
2-Methylphloroglucinol 88-03-9
Phloroglucinol 108-73-6
1-(2,4,6-Trihydroxyphenyl)ethanone 480-66-0
2,4,6-Trihydroxybenzaldehyde 487-70-7
Phloroglucinol dimethyl ether 500-99-2
1,3,5-Trimethoxybenzene 621-23-8
2,4-Diacetylphloroglucilmethane 726-28-3
2-Bromo-1,3,5-trimethoxybenzene 1131-40-4
2,4-Diacetylphloroglucinol 2161-86-6
Flopropione 2295-58-1
1,3,5-Benzenetriol triacetate 2999-40-8
2,4,6-Tribromo-1,3,5-benzenetriol 3354-82-3
2,4-Dimethylphloroglucinol 4463-02-9
Trimethylphloroglucinol 4463-03-0
1,3,5-Benzenetriol dihydrate 6099-90-7
Polyphloroglucinol phosphate 9014-68-0
2-Nitrophloroglucinol 16600-92-3
1,3,5-Trimethoxy-2-(phenylmethyl)benzene 22807-99-4
2,4-Dihydroxy-6-(3,4-dihydroxybenzoyloxy)benzoic acid 30048-34-1
Trinitrophloroglucinol lead salt 51325-28-1
Trichlorophloroglucinol 56961-23-0
2-Chloro-1,3,5-trimethoxybenzene 67827-56-9
2-Ethyl-1,3,5-trimethoxybenzene 67827-55-8
2-(3-(3-Hydroxy-4-methoxyphenyl)propyl)-1,3,5-benzenetriol 70413-04-6
Spasfon 79173-14-1
Vidalol B 137182-40-2
Vidalol A 137182-39-9
SALES SPECIFICATION

APPEARANCE

 white to off-white crystal

ASSAY

99.0% min
MELTING POINT

51 - 53 C

MOISTURE

 0.5% max
TRANSPORTATION
PACKING
25kgs in drum
HAZARD CLASS not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 28A/37/45