1-ACETYL-4-(4-HYDROXYPHENYL)PIPERAZINE

PRODUCT IDENTIFICATION
CAS NO. 67914-60-7

1-ACETYL-4-(4-HYDROXYPHENYL)PIPERAZINE

EINECS NO. 267-744-8
FORMULA C12H16N2O2
MOL WT. 220.27

H.S. CODE

  

TOXICITY

  
SMILES  
SYNONYMS 4-(1-Acetylpiperazin-4-yl)phenol; 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE off-white to pink powder
MELTING POINT 180 - 185 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and  poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a main moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine  has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants. An example of target compound from 1-acetyl-4-(4-hydroxyphenyl)piperazine is Ketoconazole widely used as an antifungal agent.
SALES SPECIFICATION

APPEARANCE

 yellow to beige powder

ASSAY

 98.0% min

MOISTURE

0.5% max
TRANSPORTATION
PACKING

25kgs in fiber drum

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 24/25