3,3'-DIINDOLYLMETHANE

PRODUCT IDENTIFICATION

CAS NO. 1968-05-4

3,3'-DIINDOLYLMETHANE

EINECS NO.  
FORMULA C17H14N2
MOL WT. 246.31

H.S. CODE

2933.99.7900

TOXICITY

 

SYNONYMS 3,3'-Diindolymethane; 3,3'-Methylenebisindole; DIM;

3,3'-methylenebis(1H-indole); 3-(1H-Indol-3-ylmethyl)-1H-indole;

SMILES c1(c[nH]c2c1cccc2)Cc1c[nH]c2ccccc12

CLASSIFICATION

Antitumor agent, Indole

EXTRA NOTES

Occurs in edible cruciferous vegetables; a cytochrome P-450 antagonist.
Anticarcinogenic Agent

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 165 - 166 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

IWikipedia Linking - Indole

Google Scholar Search

PubChem Compound Summary - 3,3'-Diindolymethane

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  3,3'-Diindolymethane

http://www.ebi.ac.uk/chebi/ -  3,3'-Diindolymethane

http://www.ncbi.nlm.nih.gov/ -  3,3'-Diindolymethane

http://www.lifeone.org/
3,3กฏ-Diindolymethane (DIM): DIM is a phytochemical from cruciferous vegetables (broccoli, Brussels sprouts, and cabbage) with the following anticancer effects: Provides a strong anti-estrogen effect on cancer cells Inhibits adhesion, motility, and invasiveness of cancer cells Inhibits 5 of the 7 procancer events

http://www.sigmaaldrich.com/c
Biochem/physiol Actions : Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

Local:
Indole-3-carbinol (I3C), found in cruciferous vegetables, is used as a dietary supplement and to make pharmaceuticals especially for anticancer drugs. It is known to inhibit cancinogenesis at the initiation stage in several animal species. But it enhances tumor incidence if administered at a post-initiation stage. It is known to lower down cholesterol. 3,3'-Diindolylmethane (DIM), a dimer of I3C, is an active derivative of indole-3-carbinol both in vivo and in vitro. DIM is known to have toxin eliminating and antiandrogenic propertie. A synthetic antiandrogenic steroid has been used in the treatment of male sexual disorders. DIM is a potential anticancer component.

SALES SPECIFICATION

APPEARANCE

white crystalline powder

PURITY

98.5% min

MELTING POINT

165 - 166 C

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards: Irritant

GHS

 

SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-H335-H413

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

 

RISK PHRASES

21/22-41-50

SAFETY PHRASES

26-29-36/37/39-61

PRICE INFORMATION