PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
3,3'-methylenebis(1H-indole); 3-(1H-Indol-3-ylmethyl)-1H-indole;
CLASSIFICATION
Antitumor agent, Indole
EXTRA NOTES
Anticarcinogenic Agent
PHYSICAL AND CHEMICAL PROPERTIES
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
Stable under ordinary conditions
EXTERNAL LINKS & GENERAL DESCRIPTION
PubChem Compound Summary - 3,3'-Diindolymethane
KEGG (Kyoto Encyclopedia of Genes and Genomes) - 3,3'-Diindolymethane
http://www.ebi.ac.uk/chebi/ - 3,3'-Diindolymethane
http://www.ncbi.nlm.nih.gov/ - 3,3'-Diindolymethane
http://www.lifeone.org/
3,3กฏ-Diindolymethane
(DIM): DIM is a phytochemical from cruciferous vegetables (broccoli,
Brussels sprouts, and cabbage) with the following anticancer effects:
Provides a strong anti-estrogen effect on cancer cells Inhibits
adhesion, motility, and invasiveness of cancer cells Inhibits 5
of the 7 procancer events
http://www.sigmaaldrich.com/c
Biochem/physiol
Actions : Acid-catalyzed reaction product of a phytochemical naturally
found in Brassicaceae, indole-3-carbinol. It functions as an antitumor
agent. This derivative can both directly stimulate apoptosis at
relatively high concentrations and sensitize TRAIL-induced apoptosis
in human cancer cells. DIM induces a G1 cell cycle arrest in human
breast cancer MCF-7 cells by a mechanism that includes increased
expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor.
The function of DIM and its derivatives as a new plant growth promoter
has been studied in an eco-friendly system.
Local:
Indole-3-carbinol
(I3C), found in cruciferous vegetables, is used as a dietary
supplement and to make pharmaceuticals especially for anticancer drugs. It is
known to inhibit cancinogenesis at the initiation stage in several animal
species. But it enhances tumor incidence if administered at a post-initiation
stage. It is known to lower down cholesterol. 3,3'-Diindolylmethane (DIM), a
dimer of I3C, is an
active derivative of indole-3-carbinol both in vivo and in vitro. DIM is known
to have toxin eliminating and antiandrogenic propertie. A synthetic
antiandrogenic steroid has been used in the treatment of male sexual disorders.
DIM is a potential anticancer component.
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APPEARANCE
PURITY
98.5% min
165 - 166 C
HAZARD OVERVIEW
OSHA Hazards: Irritant
GHS
PICTOGRAMS
HAZARD STATEMENTS
H315-H319-H335-H413
P STATEMENTS
P261-P305 + P351 + P338
RISK PHRASES
21/22-41-50
SAFETY PHRASES
26-29-36/37/39-61