4-AMINOANTIPYRINE

PRODUCT IDENTIFICATION
CAS NO. 83-07-8

4-AMINOANTIPYRINE

EINECS NO. 201-452-3
FORMULA C11H13N3O
MOL WT. 203.24

H.S. CODE

  

TOXICITY

 Oral rat LD50: 1700 mg/kg
SYNONYMS Aminoantipyrene; 4-Aminophenazone;
Ampyrone; 4-Amino-1,2-Dihydro-1,5-Dimethyl-2-Phenyl-3H-Pyrazol-3-One; 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 4-Amino-1,5-dimethyl-2- phenyl-4-pyrazolin-3-one;  4-Amino-1,2-dihydro-1,5-dimethyl-2-phenyl 3H-Pyrazol-3-one;
SMILES

 

CLASSIFICATION

 PYRAZOLONES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE Pale yellow crystals
MELTING POINT 106 - 110 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Soluble
pH Slightly alkaline
VAPOR DENSITY

 

AUTOIGNITION  

REFRACTIVE INDEX

  
NFPA RATINGS Health: 1 Flammability: 1 Reactivity: 0
FLASH POINT

 

STABILITY Stable under normal conditions

GENERAL DESCRIPTION & APPLICATIONS
Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders.

The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents.  Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine.

Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols.

SALES SPECIFICATION

APPEARANCE

 Pale yellow crystals
ASSAY (HPLC) 99.0% min
MELTING POINT 106 - 109 C

pH

7.0 - 8.0

LOI

1.0% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: