AMIDOPYRINE

PRODUCT IDENTIFICATION
CAS NO. 58-15-1

4-DIMETHYLAMINOANTIPYRINE
EINECS NO. 200-365-8
FORMULA C13H17N3O
MOL WT. 231.30

H.S. CODE

  

TOXICITY

 
SYNONYMS

Dimethylaminoazophene; 4-Dimethylaminoantipyrine;

Aminophenazone; Aminopyrine; 1-Aminopyrine; 4-Dimethylamino- 2,3-Dimethyl-1- phenyl-5-pyrazolone; 1,5-Dimethyl-4-dimethylamino- 2-phenyl-3- pyrazolone; 1-Phenyl-2,3-dimethyl- 4-dimethylaminopyrazol-5-one; 2,3-Dimethyl- 4-dimethyl Amino-1-phenyl-5- pyrazolone; 3-Keto-1,5-dimethyl-4-dimethylamino -2-phenyl-2,3-dihydropyrazole; 4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl- 2-phenyl-3H-pyrazol-3-one; 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone; 4-Dimethyl Amino-2,3- Dimethyl-1-phenyl-3-pyrazolin-5-one; 4-Dimethylaminophenazone;
SMILES

 

CLASSIFICATION

PYRAZOLONES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 107 - 109 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS Health: 2; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY

stable under ordinary conditions.

APPLICATIONS
Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders.

The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents.  Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine.

Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols.

Amidopyrine is used in manufacturing drugs especially for antipyretic, analgesic, antirheumatic and sedative agent agents. This substance has analgesic, anti-inflammatory, and antipyretic properties. But the use is discouraged due to the risk of agranulocytosis.

SALES SPECIFICATION (BP98 / USP23)

APPEARANCE

 white crystalline powder

ASSAY

99.0% min
IDENTIFICATION

pass

ASH

0.1% max

HEAVY METALS

20ppm max
MELTING POINT 107 - 109 C
LOSS ON DRYING

0.5% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases: 37/49