5-(4-CHLOROBUTYL)-1-CYCLOHEXYL-1H-TETRAZOLE

PRODUCT IDENTIFICATION
CAS NO. 73963-42-5

5-(4-CHLOROBUTYL)-1-CYCLOHEXYL-1H-TETRAZOLE
EINECS NO.  
FORMULA C11H19ClN4
MOL WT. 242.75

H.S. CODE

  

TOXICITY

 
SYNONYMS  
5-(4-Chlorobutyl)-1-cyclohexyl-tetraazacyclopentadiene; 5-(4-Chlorobutyl)- 1-cyclohexyl-1H-1,2,3,4-tetrazole;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE slightly yellow powder
MELTING POINT

 
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS

 

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions

APPLICATIONS
Intermediate for cilostazol (antithrombotic agent) which increases the concentration of cyclic adenosine monophosphate (cAMP) between dells by inhibiting the enzyme that breaks down cAMP in platelet (phosphodiesterase III).
SALES SPECIFICATION

APPEARANCE

 slightly yellow powder
ASSAY

99.0% min
HEAVY METALS

20ppm max
WATER

0.5% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: n/a, Risk Phrases: 42/43, Safety Phrases: 26-36/37/39

GENERAL DESCRIPTION OF TETRAZOLE
Tetrazole is one of a class of organic heterocyclic compounds containing a five-membered diunsaturated ring structure composed of four nitrogen atoms and one carbon atom. The simplest member of the tetrazole family is tetrazole itself, white to pale yellow crystalline solids with a weak characteristic odor; soluble in water and alcohol, melts at 156 C. Tetrazole is explosive. It is used as a gas generating agent for air bags. Shipment of tetrazole is available only as a solution in some countries. Tetrazole and its derivatives are used for biological activities such as antiviral, antibacterial, antifungal and antituberculous. They are used as catalysts in the synthesis of phosphonates.

Oligonucleotide is a short DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) sequence, typically made up of a few (2–20) covalently linked nucleotides. In molecular genetics, a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe for detecting complementary DNA or RNA. Oligonucleotides are currently used for genomic,proteomic and drug discovery technologies. Tetrazole is the traditional oligonucleotide synthesis activato for good coupling efficiency and to decrease the coupling times. But there are disadvantages of tetrazole; crystallisation problem from solution and potential explosive property at room temperature. Some alternatives have been recommended;

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