5-FLUOROURACIL

PRODUCT IDENTIFICATION
CAS NO. 51-21-8

5-FLUOROURACIL
EINECS NO. 200-085-6
FORMULA C4H3FN2O2
MOL WT. 130.08

H.S. CODE

 2933.59

TOXICITY

 Oral rat LD50: 230 mg/kg
SYNONYMS 5-Fluoro-2,4(1H,3H)-pyrimidinedione;
Fluorouracil; Fluroblastin; 5-fluoro Uracil; Arumel; Carzonal; Efudix; 5-FU; FU; 5-Fluoropyrimidine-2,4-dione; 5-Ftouracyl; Fluracil; 5-Fluoro-2,4-pyrimidinedione; 5-Fluorouracil;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystals
MELTING POINT 280 - 284 C (Decomposes)
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER slightly soluble
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS Health: 2; Flammability: 1; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY

Stable under ordinary conditions

APPLICATIONS

Antimetabolite is a chemical compound that closely resembles a metabolite in molecular structure, but can interfering with the normal reactions of the essential metabolite. It prevent the cell from the utilization of the genuine substance necessary to normal biochemical reactions. Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism and the function of important enzymes. Aminopterin (4-aminofolic acid) and methotrexate (mthylaminopterin) are antagonists of folic acid, and used in the treatment of some neoplastic diseases. Azathioprine and mercaptopurine are purine antagonists. 5-Fluorouracil and fluorodeoxyuridine are examples of pyrimidine antagonists; used as an antineoplastic and as a component of chemotherapy regimens. DNA synthesis inhibitors for antitumor effects include:

SALES SPECIFICATION

APPEARANCE

 white crystals
ASSAY

99.0% min
MELTING POINT 280 - 284 C
LOSS ON DRYING
0.5% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
REMARKS
Hazard Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases: 36/37