5-MERCAPTO-1-METHYLTETRAZOLE

PRODUCT IDENTIFICATION
CAS NO. 13183-79-4

5-MERCAPTO-1-METHYLTETRAZOLE

EINECS NO. 236-132-2
FORMULA C2H4N4S
MOL WT. 116.15

H.S. CODE

 2933.90

TOXICITY

  
SYNONYMS 1-Methyl-5-mercapto-1,2,3,4-tetrazole; MMT; MMTZ;
1-Methyl-1H-tetrazole-5-thiol; 1-Methyl-5-mercapto-1H-tetrazole; 1,2-dihydro-1-methyl-5H-Tetrazole-5-thione; 1-Methyl-5-mercaptotetrazole; 1-Methyl-5-tetrazolethione; 5-Mercapto-1-Methyl-1,2,3,4-Tetrazole; 1-Methyltetrazole-5-thiol; N-Methyltetrazolethiol;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 125 - 128 C
BOILING POINT

Decomposes

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER 126 g/l at 20 C
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT  
STABILITY

Stable under ordinary conditions

APPLICATIONS
Tetrazole is one of a class of organic heterocyclic compounds containing a five-membered diunsaturated ring structure composed of four nitrogen atoms and one carbon atom. The simplest member of the tetrazole family is tetrazole itself, white to pale yellow crystalline solids with a weak characteristic odor; soluble in water and alcohol, melts at 156 C. Tetrazole is explosive. It is used as a gas generating agent for air bags. Shipment of tetrazole is available only as a solution in some countries. Tetrazole and its derivatives are used for biological activities such as antiviral, antibacterial, antifungal and antituberculous. They are used as catalysts in the synthesis of phosphonates.

Oligonucleotide is a short DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) sequence, typically made up of a few (2–20) covalently linked nucleotides. In molecular genetics, a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe for detecting complementary DNA or RNA. Oligonucleotides are currently used for genomic,proteomic and drug discovery technologies. Tetrazole is the traditional oligonucleotide synthesis activato for good coupling efficiency and to decrease the coupling times. But there are disadvantages of tetrazole; crystallisation problem from solution and potential explosive property at room temperature. Some alternatives have been recommended;

  • 5-Ethylthio-1H-tetrazole [CAS RN: 89797-68-2]
  • 5-Methylthio-1H-tetrazole [CAS RN: 29515-99-9]
  • 5-Benzylthio-1H-tetrazole [CAS RN: 21871-47-6]
  • 5-Nitrophenyl-1H-tetrazole
  • 4,5-Dicyanoimidazole [CAS RN: 1122-28-7]

    • 5-mercapto-1-Methyl-1,2,3,4-tetrazole is used as an intermediate of Cephalosporin side chains (Cefamandole,Cefoperazone)
    SALES SPECIFICATION

    APPEARANCE

    		 white crystalline powder

    ASSAY

    99.0% mib

    WATER

    0.5% max

    MELTING POINT

    		 125 - 128 C
    TRANSPORTATION
    PACKING
    25kgs in fiber drum
    HAZARD CLASS  
    UN NO.  
    OTHER INFORMATION
    Hazard Symbols: C, Risk Phrases: 34, Safety Phrases: 26/36/37/39/45