ALBUTEROL SULFATE

ALBUTEROL SULFATE
PRODUCT IDENTIFICATION
CAS NO.	18559-94-9 35763-26-9 (base) 51022-70-9, 36519-31-0 (sulfate)
EINECS NO.	242-424-0 256-916-8
FORMULA	C₂₆H₄₂N₂O₆ · H₂SO₄
MOL WT.	288.35
H.S. CODE	2922.50.1300
TOXICITY	Oral Rat LD50: > 2500mg/kg
SYNONYMS	(±)-Salbutamol sulfate; Venetlin; DL-Albuterol sulfate;
1-(4-Hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol sulfate; Bis((tert-butyl)(beta,3,4-trihydroxyphenethyl)ammonium) sulphate; alpha(1)-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol sulfate; DL-N-tert-Butyl-2-(4-hydroxy-3-hydroxymethylphenyl)-2-hydroxyethylamine; DL-Salbutamol sulfate; alpha-((tert-Butylamino)methyl)-4-hydroxy-1,3-benzenedimethanol sulfate; 2-tert-Butylamino-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol hemisulfate;
SMILES	S(O)(=O)(=O)O.c1(cc([C@@H](CNC(C)(C)C)O)ccc1O)CO. c1(c(ccc(c1)[C@@H](CNC(C)(C)C)O)O)CO
CLASSIFICATION	Adrenergic agent, Adrenergic agonist, Adrenergic beta-agonist, Anti-Asthmatic agent, Autonomic agent, Bronchodilator, Neurotransmitter Agent, Tocolytic agent
EXTRA NOTES	A racemic mixture with a 1:1 ratio of the r-isomer, levalbuterol, and s-albuterol. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol. It is a short-acting beta2-adrenergic agonist with its main clinical use in ASTHMA.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT	240 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble
SOLVENT SOLUBILITY	Very slightly soluble in ethanol and in methylene chloride
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health hazard: 1, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT	> 250 C
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking http://www.medilexicon.com/ Mechanism of Action:In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on beta2-adrenergic receptors compared to isoproterenol. Activation of beta2-adrenergic receptors on airway smooth muscle leads to the activation of adenylcyclase, and to an increase in the intracellular concentration of cyclic-3',5'-adenosine monophosphate (cyclic AMP). This increase of cyclic AMP leads to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation. Albuterol relaxes the smooth muscles of all airways, from the trachea to the terminal bonchioles. Albuterol acts as a functional antagonist to relax the airway irrespective of the spasmogen involved, thus protecting against all bronchoconstrictor challenges. (from Ventolin HFA Product Information) Google Scholar Search http://molpharm.aspetjournals.org/ Different Ability of Clenbuterol and Salbutamol to Block Sodium Channels Predicts Their Therapeutic Use in Muscle Excitability Disorders Drug Information Portal (U.S. National Library of Medicine) - ALBUTEROL http://www.drugbank.ca/ Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
IDENTIFICATION	passes Test A,B,C,D
ASSAY	98.0 - 101.0%
CLARITY OF SOL.	BY6 max
LOSS ON DRYING	0.5% max
IMPURITIES	Individual impurity: 0.3% max, Total impurity: 1.0% max
SULPHATED ASH	0.1% max
TRANSPORTATION
PACKING
HAZARD CLASS	Not regulated
UN NO.
SAFETY INFORMATION
GHS
SIGNAL WORD	Warning
PICTOGRAMS
HAZARD STATEMENTS	H302 Harmful if swallowed
PRECAUTIONARY STATEMENTS	P264 Wash hands thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P330 Rinse mouth. P501 Dispose of contents/container to
EC DIRECTIVES
HAZARD CODES	XI Irritant
RISK PHRASES	43 May cause sensitization by skin contact
SAFETY PHRASES	36/37 Wear suitable protective clothing and gloves
PRICE INFORMATION