ALENDRONIC ACID (3-AMINO-1-HYDROXY-1-PHOSPHONO BUTYLPHOSPHONIC ACID)

ALENDRONIC ACID

PRODUCT IDENTIFICATION

CAS NO.

66376-36-1
121268-17-5 (hydrochloride)

ALENDRONIC ACID

EINECS NO.

FORMULA

C₄H₁₃NO₇P₂

MOL WT.

249.10

H.S. CODE

TOXICITY

SYNONYMS

Acidum alendronicum; Acide alendronique; Acido alendronico;

(4-Amino-1-hydroxyprobutylidene) bisphosphonic acid; 4-Amino-1-hydroxy -1-phosphono butylphosphonic acid; ácido (4-Amino-1-hidroxi butilden) bisfosfónico; Acide (4-amino-1-hydroxyprobutylidène) bisphosphonique;

CLASSIFICATION

BONE DENSITY REGULATORS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white crystalline powder

MELTING POINT

234 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

SOLVENT SOLUBILITY

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

APPLICATIONS

Alendronic acid salts belong to the class of medications called bisphosphonates which binds to the hydroxyapatite in bone and act as a inhibitor of the resorption of bone for the treatment of osteitis deformans, postmenopausal osteoporosis, and hypercalcemia related to malignancy. It is a white crystalline powder; insoluble in water. Chemically, it is described as (4-amino-1-hydroxybutylidene) bisphosphonic acid. It is administered orally. Complexed with technetium 99m, it is a radiopharmaceutical used in bone imaging.

Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as osteoporosis, metastatic disease, and Paget's disease. While bisphosphonates are analogues of endogenous pyrophosphate structurally, they are characterized by a P-C-P bond, the linking oxygen is replaced with a carbon, which is resistant to enzymatic and chemical hydrolysis. General structure is

Bisphosphonate

Side chains are responsible for chemical-physicla properties, mechanism of resorption, and pharmacokinetics. It is known that biphosphonates bind strongly to hydroxyapatite crystals at the sites of increased bone turnover preferentially and inhibit the formation, aggregation, and dissolution of the crystals.They also may inhibit osteoclast function directly, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
Bisphosphonate products include: (see belows)

Etidronic acid (CAS #: 2809-21-4)
Clodronic acid (CAS #: 10596-23-3)
Tiludronic acid (CAS #: 89987-06-4)
Medronic acid (CAS #: 1984-15-2)
Pamidronic acid (CAS #: 40391-99-9)
Neridronic acid (CAS #: 79778-41-9)
Olpadronic acid (CAS #: 63132-39-8)
Alendronic acid (CAS #: 66376-36-1)
Ibandronic acid (CAS #: 114084-78-5)
Risedronic acid (CAS #: 105462-24-6)
Zoledronic Acid (CAS #: 118072-93-8)

SALES SPECIFICATION

APPEARANCE

white crystalline powder

ASSAY

98.0% min

WATER

1.0% max

HEAVY METALS

20ppm max

TRANSPORTATION

PACKING

25kgs in fiber drum

HAZARD CLASS

UN NO.

OTHER INFORMATION

Biphosphonate (Sosium salt)	CAS #	Side Chains (R1, R2)	STRUCTURE
Alendronic acid (Alendronate)	66376-36-1	R1= -OH R2= -C₃H₆NH₂
Clodronic acid (Clodronate)	10596-23-3	R1= -Cl R2= -Cl
Etidronic acid (Etidronate)	2809-21-4	R1= -OH R2= -CH₃
Ibandronic acid (Ibandronate)	114084-78-5	R1= -OH R2= -C₂H₄N(CH₃)C₅H₁₁
Medronic acid (Medronate)	1984-15-2	R1= -H R2= -H
Neridronic acid (Neridronate)	79778-41-9	R1= -OH R2= -C₅H₁₀NH₂
Olpadronic acid (Olpadronate)	63132-39-8	R1= -OH R2= -C₂H₄N(CH₃)₂
Pamidronic acid (Pamidronate)	40391-99-9	R1= -OH R2= -C₂H₄NH₂
Risedronic acid (Risedronate)	105462-24-6	R1= -OH R2=
Tiludronic acid (Tiludronate)	89987-06-4	R1= -H R2= -S-CH₄Cl
Zoledronic Acid (Zoldronate)	118072-93-8	R1= -OH R2=

PRICE INFORMATION