AMANTADINE HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 665-66-7

AMANTADINE
EINECS NO. 211-560-2
FORMULA C10H17N·HCl
MOL WT. 187.71

H.S. CODE

  

TOXICITY

  
SYNONYMS 1-Adamantanamine hydrochloride; Amantadine, chlorhydrate;
1-Tricyclo[3.3.1.1(3,7)]decaneammonium chloride; (tricyclo[3.3.1.13,7]decyl-1-ammonium) hydrochloride; (1-Adamantylamine) hydrochloride; Amantadina, clorhidrato;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 
STABILITY Stable under normal conditions
APPLICATIONS
Amantadine is an antiviral agent against prophylactic or symptomatic influenza A in adult. In addition, it also used as an antidyskinetic in the treatment of Parkinson's syndrome and drug-induced extrapyramidal reactions. It is believed to release brain dopamine from nerve endings making it more available to activate dopaminergic receptors. The hydrochloride salt of amantadine is a white to off-white crystalline powder; freely soluble in water and soluble in alcohol and in chloroform; administered orally.The chemical desination is 1-tricyclo [3.3.1.1(3,7)] decylamine monohydrochloride.
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

Complies Test A,B

ASSAY

99.0 - 101.0%

IMPURITY

0.5% max

WATER

0.2% max

SULFATED ASH

0.1% max

SOLVENT RESIDUES

0.1% max

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
25kgs in  fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-36

GENERAL DESCRIPTION OF ADAMANTANE

Adamantane consists of four cyclohexanes fused each other in chair conformations. It is the most stable isomer of formula, C10H16; one of  the highest melting point hydrocarbons (> 210 C); boiling point cannot be determined directly as it sublimes easily. Its stability is from strain free and highly symmetrical structure (all C-C bonds are set in and all Cs are tetrahedral). Its systematical name is tricyclo[3.3.1.1(3,7)]decane which means bicyclo[3.3.1]decane with an extra one-carbon bridge between C3 and C7. An alkyl substituent is axial in one ring and equatorial in another. Polymantanes have the same structure as the diamond lattice featuring highly symmetrical and strain free and are named as diamondoids . The general molecular formula of homologous diamondoid is C4n+6H4n+12. Diamondoids have one or more cages and are called diamantane, triamantane, and polymantanes. There are numerous structural isomers as well. Aadamantane itself is the simplest diamondoid. Some examples are; iceane (C12H18), diadamantane (C14H20), triadamantane (C18H24), isotetramantane (C22H28), cyclohexamantane (C26H30), superadamantane (C35H36). Natural diamondoids are extracted and purified from petroleum deposits. Diamondoids are being investigated in the new field of nanotechnoloy. Clinically, amantane and its derivatives are employed chiefly for the synthesis of antiviral drugs as well as neurological drugs such as rimantadine and Parkinson¡¯s disease drugs. Their unique structures have the possibility to be applied to produce a broad range of biologically and pharmaceutically active drugs such as anticancer and anti-microbial agents.