|
|
|
| AZTREONAM | ||
|
PRODUCT IDENTIFICATION |
||
| CAS NO. | 78110-38-0 80951-91-3 149496-40-2 |
|
| EINECS NO. | 278-839-9 | |
| FORMULA | C13H19N5O8S2 | |
| MOL WT. | 437.441 | |
|
H.S. CODE |
||
|
TOXICITY |
||
| SYNONYMS | Azactam; | |
| (Z)-2-[[[(2-amino-4-thiazolyl)[[(2S,-3S)-2-methyl-4- oxo-1-sulfo-3-azetidinyl]carbamoyl] methylene] amino] oxy]-2-methyl propionic acid; [2S-[2alpha,3beta(Z)]]-2- [[[1-(2- Amino-4-thiazolyl)- 2-[(2-methyl-4-oxo-1-sulfo- 3-azetidinyl) amino]-2-oxo ethylidene] amino] oxy]-2-methylpropanoic acid; 2-[(Z-(2)-Aminothiazol-4-yl)-2-[(2S,3S)-2- methyl-4- oxo-1-sulfoazetidin-3-yl carbamoyl] methyleneaminooxy]-2- methyl-1-propanoic acid; | ||
| SMILES |
|
|
|
CLASSIFICATION |
||
|
PHYSICAL AND CHEMICAL PROPERTIES |
||
| PHYSICAL STATE | white to off-white crystals | |
| MELTING POINT | ||
| BOILING POINT |
|
|
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | ||
| pH | ||
| VAPOR DENSITY |
|
|
|
AUTOIGNITION |
||
|
NFPA RATINGS |
Health: 1; Flammability: 0; Instability: 0 | |
|
REFRACTIVE INDEX |
|
|
| FLASH POINT | ||
| STABILITY |
Stable under ordinary conditions. |
|
|
APPLICATIONS |
||
| Aztreonam is a monobactam (monocyclic beta-lactam nucleus) antibiotic. It has side chains for activity enhencing and stability. It inhibits cell wall biosynthesis by binding to penicillin-binding protein of aerobic gram-negative bacilli. It has very active and broad spectrum activity against aerobic-gram negative bacteria, including Pseudomonas aeruginosa, Hemophilus influenzae, Enterobacteriaceae, and Neisseria gonorrhea; This spectrum is similar to the 3rd generation cephalosporins or aminoglycosides. As it has limited activity to only aerobic-gram negative bacteria, it is used in combination with gram-positive bacteria anaerobes sometimes. It is frequently used in patients unable to tolerate beta-lactams.It is resistant to beta-lactamases and is useful against gram-negative pathogens. The chemical designation is 2-[(Z-(2)-Aminothiazol-4-yl)-2-[(2S,3S)-2-methyl-4- oxo-1-sulfoazetidin-3-yl carbamoyl] methyleneaminooxy]-2- methyl-1-propanoic acid. It is a white crystalline powder, odorless. Commercial aztreonam is the mixture with arginine (apprx 4:3). | ||
| SALES SPECIFICATION | ||
|
APPEARANCE |
white to off-white crystals | |
|
IDENTIFICATION |
Complies |
|
|
ASSAY |
90.0% min |
|
| pH | 4.5 - 7.5 | |
|
WATER |
2.0% max |
|
|
STERILITY |
Sterile |
|
|
ARGININE |
40.0 - 45.0% |
|
| TRANSPORTATION | ||
| PACKING |
|
|
| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 22-24/25 | ||
|
|
|
