PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
REFRACTIVE INDEX
Stable under ordinary conditions. Moisture sensitive
GENERAL DESCRIPTION & APPLICATIONS
Benzonatate is used for symptomatic relief of cough. Benzonatate may be effective in suppressing cough in acute respiratory conditions such as pneumonia, bronchitis, pertussis, and the common cold; and in chronic diseases such as pulmonary emphysema, bronchial asthma, tuberculosis, and pulmonary tumor. Benzonatate has been shown to be more effective than codeine in reducing the frequency of experimentally induced cough, and may be effective in providing symptomatic relief in patients with opiate-resistant cough. Because of the drug’s rapid, pronounced local anesthetic effect, benzonatate has been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules (e.g., by chewing or dissolving two 100-mg liquid-filled capsules in the mouth) to provide sufficient oropharyngeal anesthesia for conscious intubation. This method of administration must not be employed when the drug is used as an antitussive because of the risk of potentially life-threatening complications resulting from local effects of the drug on the oropharyngeal tract. (source: http://www.ashp.org/)
Benzonatate is a peripherally acting antitussive that prevents or relieves minor coughing by anesthetizing the stretch receptors in the respiratory passages, lungs, and pleura. The chemical designation is 2,5,8,11,14,17,20, 23,26- nonaoxaoctacosan-28-yl-p-(butylamino) benzoate.USP
APPEARANCE
IDENTIFICATION
Complies Test A, Test B
ASSAY
95.0% - 105.0%
REFRACTIVE INDEX
1.509 -1.511 at 20 C
WATER
0.3% max
CHLORIDE
0.00-035% max
SULFATE
0.05% max
HEAVY METALS
10ppm max
SOLVENT RESIDUE
2.5% max