CEFIXIME TRIHYDRATE

CEFIXIME TRIHYDRATE
PRODUCT IDENTIFICATION
CAS NO.	79350-37-1 (Anhydrous) 125110-14-7 (Trihydrate)
EINECS NO.
FORMULA	C₁₆H₁₅N₅O₇S₂·3H₂O
MOL WT.	507.50
H.S. CODE	2941.90.3000
TOXICITY	Oral Rat LD50: > 10gm/kg
SYNONYMS	Cefixim; Cefixima; Cefiximum; Cefixoral; Cefspan; Cephoral;
(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0)oct-2-ene- 2-carboxylic acid 7(2)-(Z)-(O-(carboxymethyl)oxime) trihydrate; Unixime; (6R,7R)-7-(2-(2-Amino-4- thiazolyl)glyoxylamido)-8--oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0)oct-2-ene-2-carboxylic acid, 7(2)-(Z)-(O- (carboxymethyl)oxime)trihydrate; Other RN: 214265-67-5
SMILES	N12C(C(O)=O)=C(C=C)CS[C@@H]2[C@@H](NC(=O)\C(=N\OCC (=O)O)c2nc(sc2)N)C1=O.O.O.O
CLASSIFICATION	Third generation cephalosporin
EXTRA NOTES	A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to yellowish crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
AUTOIGNITION
log P	0.12 (Octanol-water)
OH RATE CONSTANT	1.36E-10 (cm3/molecule-sec at 25 C Atmospheric)
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Cefixime PubChem Compound Summary - Cefixime http://www.drugbank.ca Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall. Local: A 3rd generation cephalosporin; resistant to hydrolysis by beta-lactamases; administered orally. Effective against a wide range of bacteria, used in the treatment of otitis media, bronchitis, pharyngitis, tonsillitis, gonorrhea, and urinary tract infections; Cefotaxime analog
SALES SPECIFICATION
APPEARANCE	white to yellowish crystalline powder
ASSAY	950 ~ 1030��/��
WATER (K.F.)	9.0 ~ 12.0%
SOLUTION CLARITY	clear, transparent
SPECIFIC ROTATION	-77° ~ -88°
pH	2.6 ~ 4.1
HEAVY METALS	20ppm max
INDIVIDUAL IMPURITY	0.5% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
Hazard OVERVIEW	Irritant
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H317 May cause an allergic skin reaction H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
PRECAUTIONARY STATEMENTS	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P342 + P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
EC DIRECTIVES
HAZARD CODES	Xn Harmful
RISK PHRASES	42/43 May cause sensitization by inhalation and skin contact
SAFETY PHRASES	22 Do not breathe dust 36/37 Wear suitable protective clothing and gloves 45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
PRICE INFORMATION