CEFTAZIDIME PENTAHYDRATE

PRODUCT IDENTIFICATION

CAS NO. 72558-82-8 (Anhydrous)
78439-06-2 (Pentahydrate)

CEFTAZIDIME

EINECS NO. 276-715-9
FORMULA C22H22N6O7S2· 5H2O
MOL WT. 636.65

H.S. CODE

2941.90.3000

TOXICITY

 
SYNONYMS Ceftazidima; CAZ pentahydrate;
1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl] methyl] pyridinum, hydroxide, inner salt, pentahydrate; Ceptaz; Fortaz; (6R-(6alpha,7beta(Z)))-1-((7-(((2-Amino-4-thiazolyl) ((1-carboxy-1-methylethoxy )imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1- azabicyclo(4.2.0)oct-2-en-3-yl) methyl)pyridinium
SMILES O.O.O.O.O.C(C(=O)O)(C)(C)O/N=C(\c1nc(sc1)N)C(=O)N[C@@ H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])C[n+]1ccccc1

CLASSIFICATION

Third generation cephalosporin, Thiazole, Pyridine, Zwitterion

EXTRA NOTES

Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Contains sodium carbonate (10%) as stabilizer

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White to off-white powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 398 mg/l at 25 C
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

log P -1.60E+00 (Octanol-water)
VAPOR PRESSURE 2.32E-21 (mmHg at 25 C)
HENRY LAW CONSTANT 2.46E-34 (atm-m3/mole at 25 C)
OH RATE CONSTANT 1.31E-10 (cm3/molecule-sec at 25 C Atmospheric)

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Ceftazidime

PubChem Compound Summary - Ceftazidime

http://www.drugbank.ca
Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration. Ceftazidime is bactericidal in action exerting its effect by inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin binding protein 3 (PBP3). A wide range of gram-negative organisms is susceptible to ceftazidime in vitro, including strains resistant to gentamicin and other aminoglycosides. In addition, ceftazidime has been shown to be active against gram-positive organisms. It is highly stable to most clinically important beta-lactamases, plasmid or chromosomal, which are produced by both gram-negative and gram-positive organisms and, consequently, is active against many strains resistant to ampicillin and other cephalosporins. Ceftazidime has activity against the gram-negative organisms
Pseudomonas and Enterobacteriaceae. Its activity against Pseudomonas is a distinguishing feature of ceftazidime among the cephalosporins.

Local:
Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium  and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. Third-generation cephalosporins are more active against gram-negative organisms but less active against gram-positive organisms than second-generation agents; examples are cefoperazone, cefotaxime, ceftriaxone, ceftazidime, ceftizoxime, and moxalactam.

SALES SPECIFICATION

APPEARANCE

White to off-white powder

ASSAY

90.0 - 102.0% (on anhydrous basis)
WATER (K.F.) 13.5% max
SOLUTION CLARITY clear, transparent
STERILITY sterile

pH

5.0 - 7.5

HEAVY METALS

20ppm max

INDIVIDUAL IMPURITY

0.5% max
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

Hazard OVERVIEW

Irritant

GHS

 

SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H317  May cause an allergic skin reaction
H319  Causes serious eye irritation
H334  May cause allergy or asthma symptoms or breathing difficulties if inhaled

PRECAUTIONARY STATEMENTS

P261  Avoid breathing dust/fume/gas/mist/vapours/spray.
P280  Wear protective gloves/protective clothing/eye protection/face protection.
P305 + P351 + P338  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P342 + P311  IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

EC DIRECTIVES

 

HAZARD CODES

Xn Harmful

RISK PHRASES

42/43  May cause sensitization by inhalation and skin contact

SAFETY PHRASES

22  Do not breathe dust
36/37  Wear suitable protective clothing and gloves
45  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

PRICE INFORMATION