CEFTAZIDIME

CEFTAZIDIME PENTAHYDRATE
PRODUCT IDENTIFICATION
CAS NO.	72558-82-8 (Anhydrous) 78439-06-2 (Pentahydrate)
EINECS NO.	276-715-9
FORMULA	C₂₂H₂₂N₆O₇S₂· 5H₂O
MOL WT.	636.65
H.S. CODE	2941.90.3000
TOXICITY
SYNONYMS	Ceftazidima; CAZ pentahydrate;
1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl] methyl] pyridinum, hydroxide, inner salt, pentahydrate; Ceptaz; Fortaz; (6R-(6alpha,7beta(Z)))-1-((7-(((2-Amino-4-thiazolyl) ((1-carboxy-1-methylethoxy )imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1- azabicyclo(4.2.0)oct-2-en-3-yl) methyl)pyridinium
SMILES	O.O.O.O.O.C(C(=O)O)(C)(C)O/N=C(\c1nc(sc1)N)C(=O)N[C@@ H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])C[n+]1ccccc1
CLASSIFICATION	Third generation cephalosporin, Thiazole, Pyridine, Zwitterion
EXTRA NOTES	Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients. Contains sodium carbonate (10%) as stabilizer
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	White to off-white powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	398 mg/l at 25 C
pH
VAPOR DENSITY
AUTOIGNITION
log P	-1.60E+00 (Octanol-water)
VAPOR PRESSURE	2.32E-21 (mmHg at 25 C)
HENRY LAW CONSTANT	2.46E-34 (atm-m3/mole at 25 C)
OH RATE CONSTANT	1.31E-10 (cm3/molecule-sec at 25 C Atmospheric)
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Ceftazidime PubChem Compound Summary - Ceftazidime http://www.drugbank.ca Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration. Ceftazidime is bactericidal in action exerting its effect by inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin binding protein 3 (PBP3). A wide range of gram-negative organisms is susceptible to ceftazidime in vitro, including strains resistant to gentamicin and other aminoglycosides. In addition, ceftazidime has been shown to be active against gram-positive organisms. It is highly stable to most clinically important beta-lactamases, plasmid or chromosomal, which are produced by both gram-negative and gram-positive organisms and, consequently, is active against many strains resistant to ampicillin and other cephalosporins. Ceftazidime has activity against the gram-negative organisms Pseudomonas and Enterobacteriaceae. Its activity against Pseudomonas is a distinguishing feature of ceftazidime among the cephalosporins. Local: Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. Third-generation cephalosporins are more active against gram-negative organisms but less active against gram-positive organisms than second-generation agents; examples are cefoperazone, cefotaxime, ceftriaxone, ceftazidime, ceftizoxime, and moxalactam.
SALES SPECIFICATION
APPEARANCE	White to off-white powder
ASSAY	90.0 - 102.0% (on anhydrous basis)
WATER (K.F.)	13.5% max
SOLUTION CLARITY	clear, transparent
STERILITY	sterile
pH	5.0 - 7.5
HEAVY METALS	20ppm max
INDIVIDUAL IMPURITY	0.5% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
Hazard OVERVIEW	Irritant
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H317 May cause an allergic skin reaction H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
PRECAUTIONARY STATEMENTS	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P342 + P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
EC DIRECTIVES
HAZARD CODES	Xn Harmful
RISK PHRASES	42/43 May cause sensitization by inhalation and skin contact
SAFETY PHRASES	22 Do not breathe dust 36/37 Wear suitable protective clothing and gloves 45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
PRICE INFORMATION