CEFTEZOLE SODIUM

PRODUCT IDENTIFICATION

CAS NO. 26973-24-0 (parent)
41136-22-5 (sodium)

CEFTEZOLE SODIUM

EINECS NO.  
FORMULA C13H11N8O4S3·Na
MOL WT. 462.45

H.S. CODE

2941.90.5000

TOXICITY

Oral Rat LD50: > 20gm/kg
SYNONYMS Ceftezole sodium; Alomen; Celoslin; Falomesin;
Sodium (6R-trans)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-3 -((1,3,4-thiadiazol-2 -ylthio) methyl)- 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylate; (6R-trans)-8-Oxo-7-((1H-tetrazol-1-ylacetyl)amino )-3-((1,3,4-thiadiazol-2-ylthio) methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt; Ceftezol;
SMILES [Na+].N12C(=C(CS[C@@H]2[C@@H](C1=O)NC(=O)Cn1nnnc1) CSc1scnn1)C(=O)[O-]

CLASSIFICATION

Antiboitics / Cephalosporins /

EXTRA NOTES

1st generation cephalosporin

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 313 mg/l at 25 C
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

log P -0.67 (Octanol-water)
VAPOR PRESSURE 3.63E-18 (mmHg at 25 C)
HENRY LAW CONSTANT 1.82E-23 (atm-m3/mole at 25 C)
OH RATE CONSTANT 1.27E-10 (cm3/molecule-sec at 25 C Atmospheric)

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - CEFTEZOLE

PubChem Compound Summary - CEFTEZOLE

http://www.ncbi.nlm.nih.gov/
Ceftezole, a new cephalosporin C derivative II. Distribution and excretion in parenteral administration.

http://www.spandidos-publications.com/
Ceftezole, a cephem antibiotic, is an ¥á-glucosidase inhibitor with in vivo anti-diabetic activity

http://aac.asm.org/
The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of which B. fragilis G-232 was a typical sample, was resistant to ceftezole (MIC, 100 uig/ml), cefazolin (MIC, 100 ,g/nl), and cephalothin (MIC, 200 ,ug/ml) but not cefoperazone (MIC, 6.25 jLg/ml) or cefamandole (MIC, 25 ,ug/ml). On the basis of studies of stability to ,B-lactamase, outer membrane permeation, and affinity for penicillin-binding proteins (PBPs), we conclude that decreased affinity for PBP 3 may play an i mportant role in the resistance to ceftezole, cefazolin, and cephalothin in B. fragilis G-232. Another group (also ca. 15%), of which B. fragilis G-242 was a representative, was resistant to all five cephalosporins (MIC, 100 to 400 ,ug/ml) and produced a high amount of ,B-lactamase. Similar broad-spectrum resistance was seen in a mutant of strain G-232 that had a greater-than-30-fold increase in P-lactamase production.

SALES SPECIFICATION

APPEARANCE

White to yellowish crystalline powder

ASSAY

860§¶/§· min
LOSS ON DRYING 5.0% max
SPECIFIC ROTATION -5° ~ -9°

pH

4.5 - 6.5

HEAVY METALS

20ppm max

BULK DENSITY 0.4g/§¢
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

Hazard OVERVIEW

Irritant

GHS

 

SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H317  May cause an allergic skin reaction
H319  Causes serious eye irritation
H334  May cause allergy or asthma symptoms or breathing difficulties if inhaled

PRECAUTIONARY STATEMENTS

P261  Avoid breathing dust/fume/gas/mist/vapours/spray.
P280  Wear protective gloves/protective clothing/eye protection/face protection.
P305 + P351 + P338  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P342 + P311  IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

EC DIRECTIVES

 

HAZARD CODES

Xn Harmful

RISK PHRASES

42/43  May cause sensitization by inhalation and skin contact

SAFETY PHRASES

22  Do not breathe dust
36/37  Wear suitable protective clothing and gloves
45  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

PRICE INFORMATION