CHLORHEXIDINE ACETATE

PRODUCT IDENTIFICATION
CAS NO. 56-95-1

CHLORHEXIDINE 

EINECS NO. 200-302-4
FORMULA C22H30Cl2N10.2CH3COOH·H2O
MOL WT. 625.56

H.S. CODE

  

TOXICITY

  
SYNONYMS 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane;
Hibitane Diacetate; 1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide); Arlacide A; Bactigras; Chlorhexidine acetate; Chlorhexidine diacetate hydrate; Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate; Nolvasan; Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, diacetate; Chlorohexidine Diacetate;
SMILES

 

CLASSIFICATION

DISINFECTANTS /

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

White to pale yellow powder

MELTING POINT

153 - 156 C

BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER

19 - 20 (g/l at 20 C)

pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Chlorhexidine is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms, facultative anaerobes, aerobes, and yeast. Chlorhexidine is used as an ingredient of bacteriostatic and bacteriocidal by the activity of membrane disruption in a general purpose skin general skin cleansers, surgical scrub, germicidal hand rinses and animal disinfection products. It is used as a topical antiinfective for mucous membranes and as a preservative for eye drops. Chlorhexidine is also used as an antiseptic ingredient used in mouthwash to prevent oral plaque, oral bacteria and in treating gingivitis. Its salts for commercial uses include:
Chlorhexidine salt

CAS RN
Chlorhexidine diacetate 56-95-1
Chlorhexidine dihydrochloride 3697-42-5
Chlorhexidine digluconate 18472-51-0
Chlorhexidine phosphanilate 77146-42-0

In addition to antibacterial activity, chlorhexidine phosphanilate is also used as a spermatocidal agent.

Active ingredients in mouthwash or dental caries prophylactic include;

Ingredient

CAS RN
Amosan 8059-88-9
Benzalkonium chloride 8001-54-5
Cetylpyridinium chloride 123-03-5
Chlorhexidine gluconate 18472-51-0
Chlorhexidine55-56-1
Dectaflur 36505-83-6
Eucalyptol 470-82-6
Hetaflur 3151-59-5
Hydrogen peroxide 7722-84-1
Ipexidine mesylate 69017-90-9
Listerine 51273-66-6
Meridol 120812-75-1
Metesculetol 52814-39-8
Methyl salicylate 119-36-8
Olaflur 6818-37-7
Rhatany 84775-95-1
Salifluor 78417-90-0
Sanguinarine 2447-54-3
Sodium monofluorophosphate 10163-15-2
Sodium fluoride 7681-49-4
Stannous fluoride 7783-47-3
Thymol 89-83-8
Tiodonium chloride 38070-41-6
Zinc chloride 7646-85-7
Zinc fluoride 7783-49-5
SALES SPECIFICATION (CP/USP/BP)
APPEARANCE

White to pale yellow powder

IDENTITY

Complies (IR Spectrum)

CONTENT

 98.0 - 102.0% (HPLC)

MELTING POINT

153 - 156 C

RESIDUE ON IGNITION

0.15% max

WATER

3.5% max

p-CHLORO ANILINE

 0.05% max
TRANSPORTATION
PACKING

25kgs in Drum

HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases: 20/21/36, Safety Phrases: 25/28A/33/37/39/45
GENERAL DESCRIPTION OF ANTISEPTIC AGENT
Antiseptic agent is a substance which kills or inhibits the growth of disease-causing bacteria and other microorganisms. It is essentially nontoxic to be applied to the skin or mucous membranes. (Disinfectant including cresol, bleaching powder, and phenol is in general toxic to cells of the body). Common antiseptic agents are Benzalkonium Chloride, Cetrimide, Chlorhexidine, Hexachlorophene, Iodine Compounds, Mercury Compounds (Thimerosol), Alcohol and Hydrogen Peroxide, Hexamine Hippurate, Triclosan, Cetylpyridinium Chloride, And Dequalinium. Other substances which can be used for antiseptic purpose include Boric acid and volatile oils such as Methyl Salicylate.
Hexachlorophene and Benzalkonium Chloride are used primarily in hand or face washes. Benzalkonium Chloride must not be applied to areas which have not been fully rinsed as it is inactivated by organic compounds. Benzalkonium application many include disinfecting instruments and preservativing drugs in low concentration form.
Iodine compounds have the widest spectrum of antiinfectives against bacteria, fungi, spores, protozoa, viruses, and yeasts. Aqueous iodine are less effective than alcoholic solutions, but alcoholic component is drying and irritating to abraided skin. Povidone iodine is convenient to use as it is less irritating, but not as effective.
Chlorhexidine is used as a safe antiseptic or disinfectant to apply to prevent body infection and in oral rinses for treating sore gums and mouth ulcers and preventing plaque on teeth. It is used in the form of acetate, gluconate or hydrochloride, either alone or in combination with others such as cetrimide.
Cetrimide is an antiseptic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treating seborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums.
Hippuric Acid, an amino acid glycine, is excreted from the body and is used in urinary system drugs. Hexamine hippurates is helpful for preventing and treating infections of the urinary system; it acts by being transformed to formaldehyde.
Triclosan is a very popular antibacterial agent. It is used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics and textiles for antibacterial activity purpose.
Cetylpyridinium chloride is used in oral rinses for cleaning mouth and treating minor throat or mouth infections and teething problems.
Dequalinium chloride is antiinfectives against bacteria and fungi. It is used in treating bacterial or fungal infections of mouth and throat.
PRICE

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