CLADRIBINE

PRODUCT IDENTIFICATION
CAS NO. 4291-63-8

CLADRIBINE

EINECS NO.  
FORMULA C10H12ClN5O3
MOL WT. 285.69

H.S. CODE

  

TOXICITY

  
SYNONYMS 2-chloro-2'-deoxyadenosine; 2-Cl-dAdo; CdA;
2-Chloro-6-amino-9-(2-deoxy-b-D-erythropento-furanosyl) purine;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 210 - 220 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER
 
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 

FLASH POINT  
STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Cladribine,a chlorinated purine antimetabolite (2-chlorodeoxyadenosine) resistant to adenosine deaminase. It hase immunosuppressive activity and is used as an antineoplastic agent in the treatment of hairy cell leukemia. It is used as an intermediate for the modification of nucleosides and nucleotides and for cytobiology research. The chemical designation is 2-chloro-6-amino- 9-(2-deoxy-b-D-erythropento- furanosyl) purine.

Antimetabolite is a chemical compound that closely resembles a metabolite in molecular structure, but can interfering with the normal reactions of the essential metabolite. It prevent the cell from the utilization of the genuine substance necessary to normal biochemical reactions. Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism and the function of important enzymes. Aminopterin (4-aminofolic acid) and methotrexate (mthylaminopterin) are antagonists of folic acid, and used in the treatment of some neoplastic diseases. Azathioprine and mercaptopurine are purine antagonists. 5-Fluorouracil and fluorodeoxyuridine are examples of pyrimidine antagonists; used as an antineoplastic and as a component of chemotherapy regimens. DNA synthesis inhibitors for antitumor effects include:

SALES SPECIFICATION

APPEARANCE

 white crystalline powder
PURITY (HPLC)

98.0% min

MELTING POINT

210 - 220 C
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 23/24/25-36/37/38, Safety Phrases: 22-26-36-45
PRICE