| CAS
NO. |
18323-44-9
(Base)
21462-39-5 (Hydrochloride)
24729-96-2 (Phosphate)
25507-04-4 (Palmitate hydrochloride) |
|
| EINECS
NO. |
242-209-1,
244-398-6, 246-433-0 |
| FORMULA |
C18H33ClN2O5S |
| MOL
WT. |
424.98 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
7(S)-Chloro-7-deoxylincomycin; Cleocin;
|
| 7-Deoxy-7(S)-chlorolincomycin;
Klimicin Methyl
xamido)-1-thio-L-threo-alpha-D-galacto- octopyranoside;
L-threo-alpha-D-galacto-Octopyranoside, methyl
7-chloro-6,7,8-trideoxy-6- (((1-methyl-4-propyl-2-pyrrolidinyl)carbon yl)
amino)-1-thio-, (2S-trans)-, Hydrochloride monohydrate; Methyl
7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4- propyl-L-2-pyrrolidine carboxamido)-1-thio-L-threo-
alpha-D-galacto-octopyranoside;
Methyl 7-cloro-6, 7, hio-L-threo-alpha-D-galacto-octopyranosido; |
| SMILES |
|
| CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white crystalline powder |
| MELTING
POINT |
141 - 143 C |
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR
DENSITY |
|
| AUTOIGNITION |
|
| NFPA
RATINGS |
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
APPLICATIONS
|
Clindamycin is a semisynthetic analogue of the natural antibiotic lincomycin
from which it is produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl
group of lincomycin; antibacterial and antiprotozoal antibiotic of the licosamide class
that inhibits protein synthesis in bacterial by binding the 50s ribosomal
subunit. It is active mainly toward gram-positive microorganisms. It
is used primarily in the treatment of penicillin-resistant infections and in
patients allergic to penicillin. It may be used alone or with one or more other
medicines. Chemical name of clindamycin is Methyl 7-chloro-6,7,8-trideoxy- 6-(1
-methyl-trans-4-propyl-L-2-pyrrolidine- carboxamido)-1
-thio-L-threo-a-o-galacto- octopyranoside.
- Clindamycin Hydrochloride: the
hydrochloride salt of clindamycin; white crystalline powder; administered
orally.
- Clindamycin Palmitate Hydrochloride: The palmitic ester of
clindamycin in hydrochloride form; white crystalline powder ; soluble in water
for the preparation of solutions; administered orally.
- Clindamycin Phosphate:
The phosphoric acid ester of clindamycin; white crystalline powder ; soluble in
water; administered intramuscularly or intravenously.
|
| SALES
SPECIFICATION |
|
Clindamycin Hydrochloride
(BP) |
|
APPEARANCE
|
white crystalline powder |
|
IDENTIFICATION
|
Complies
Test A, B, C,D
|
|
ASSAY
|
84.0
- 93.0%
|
|
OPTICAL
ROTATION
|
+135° ~ +150° |
|
WATER
|
3.0
- 6.0%
|
|
SOLUTION
CLARITY
|
Complies
|
|
SULFATED
ASH
|
0.5%
max
|
|
RELATED
SUBSTANCE
|
3.0%
max (Individual Impurity: 2.0% max)
|
|
Clindamycin Phosphate
(USP) |
|
APPEARANCE
|
white crystalline powder |
|
IDENTIFICATION
|
Complies
Test A, B
|
|
ASSAY
|
90.0
- 101.00%
|
|
POTENCY
|
758
µm/mg
|
|
OPTICAL
ROTATION
|
+115° ~ +130° |
|
pH
|
3.5
- 4.5
|
|
ASSAY
|
|
|
WATER
|
6.0%
max
|
|
BACTERCAL ENDOTOXIC |
Complies
|
|
RELATED
SUBSTANCE
|
4.0%
max (Individual Impurity: 2.0% max)
|
| TRANSPORTATION |
| PACKING |
25kgs
in drum
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
| Hazard Symbols: , Risk Phrases: ,
Safety Phrases: 22-24/25 |