CODEINE MONOHYDRATE-HCl

PRODUCT IDENTIFICATION

CAS NO. 76-57-3 (Base)
1422-07-7 (Hydrochloride)

CODEINE

EINECS NO.  
FORMULA C18H21NO3·H2O
MOL WT. 317.38

H.S. CODE

 
SMILES

 

TOXICITY

Oral rat LD50: 427 mg/kg
SYNONYMS Methyl morphine monohydrate;
7,8-Didehydro-4,5-alpha-epoxy-3-methoxy-17-methylmorphinan- 6-alpha-ol; 3-o-methylmorphine Monohydrate; 7,8-Didehydro-4,5-epoxy-3-methoxy- 17-methyl-(5alpha, 6alpha)-morphinan 6-ol; Actacode; Calcidrine; Codicept; Codalgin Forte Codate; (-)-Codeine; Codeinum; Coducept; Metilmorfina; Morphine-3-methyl ether; Morphine monomethyl ether; N-Methyl Norcodine;

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 154 - 156 C
BOILING POINT 250 C
SPECIFIC GRAVITY 1.32
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS Health: 3 Flammability: 1 Reactivity: 1

REFRACTIVE INDEX

 
FLASH POINT

75 C

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Codeine is an alkaloid found naturally in opium in concentrations ranging from 0.7 to 2.5 percent. It is commercially synthesized from morphine. It is the most widely used drug among the morphine class of compounds used in a variety of pharmaceuticals including analgesics, antiperistaltics, antitussive agents, hypnotics, and sedatives. Codeine is an opioid analgesic related to morphine but with less potential analgesic property and mild sedative effect. Dihydrocodeine, called also drocode, is a similar opioid analgesic with pharmaceutical action with codeine. It is known it has approximately twice potentiality. It has also been used as an antitussive.

SALES SPECIFICATION

APPEARANCE

white crystalline needles

PURITY

99.0% min (Dry Basis)

OPTICAL ROTATION

-106° ~ -110° (C=1 in water)

WATER

10.0% max

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: 20/21/22, Safety Phrases: 26-36