CODEINE (3-o-METHYLMORPHINE)

CODEINE MONOHYDRATE-HCl

PRODUCT IDENTIFICATION

CAS NO.

76-57-3 (Base)
1422-07-7 (Hydrochloride)

CODEINE

EINECS NO.

FORMULA C₁₈H₂₁NO₃·H₂O

MOL WT. 317.38

H.S. CODE

SMILES

TOXICITY

Oral rat LD50: 427 mg/kg

SYNONYMS Methyl morphine monohydrate;

7,8-Didehydro-4,5-alpha-epoxy-3-methoxy-17-methylmorphinan- 6-alpha-ol; 3-o-methylmorphine Monohydrate; 7,8-Didehydro-4,5-epoxy-3-methoxy- 17-methyl-(5alpha, 6alpha)-morphinan 6-ol; Actacode; Calcidrine; Codicept; Codalgin Forte Codate; (-)-Codeine; Codeinum; Coducept; Metilmorfina; Morphine-3-methyl ether; Morphine monomethyl ether; N-Methyl Norcodine;

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder

MELTING POINT 154 - 156 C

BOILING POINT 250 C

SPECIFIC GRAVITY 1.32

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS Health: 3 Flammability: 1 Reactivity: 1

REFRACTIVE INDEX

FLASH POINT

75 C

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Codeine is an alkaloid found naturally in opium in concentrations ranging from 0.7 to 2.5 percent. It is commercially synthesized from morphine. It is the most widely used drug among the morphine class of compounds used in a variety of pharmaceuticals including analgesics, antiperistaltics, antitussive agents, hypnotics, and sedatives. Codeine is an opioid analgesic related to morphine but with less potential analgesic property and mild sedative effect. Dihydrocodeine, called also drocode, is a similar opioid analgesic with pharmaceutical action with codeine. It is known it has approximately twice potentiality. It has also been used as an antitussive.

SALES SPECIFICATION

APPEARANCE

white crystalline needles

PURITY

99.0% min (Dry Basis)

OPTICAL ROTATION

-106° ~ -110° (C=1 in water)

WATER

10.0% max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: , Risk Phrases: 20/21/22, Safety Phrases:26-36