DAIDZEIN

PRODUCT IDENTIFICATION
CAS NO. 486-66-8

DAIDZEIN

EINECS NO. 207-635-4
FORMULA C15H10O4
MOL WT. 254.24

H.S. CODE

 2933.99.7900

TOXICITY

  
SYNONYMS 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone;
7-Hydroxy-3-(4-hydroxy­phenyl)­chromone; 7-Hidroxi-3-(4-hidroxifenil)-4-benzopirona; 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one; 4',7-Dihydroxyisoflavone;
SMILES

Oc1ccc2c(=O)c(c3ccc(O)cc3)coc2c1

CLASSIFICATION

Isoflavone, Non-Steroidal estrogen, Phytoestrogen, Protein Tyrosine Kinase (PTK) Inhibitor

EXTRA NOTES

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT

 

BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Insoluble
SOLVENT SOLUBILITY

Soluble in DMSO

pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Daidzein

Google Scholar Search - Daidzein

Drug Information Portal (U.S. National Library of Medicine) - Daidzein

PubChem Compound Summary - Daidzein

Drug Bank -  Daidzein

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Daidzein

http://www.ebi.ac.uk/ - Daidzein

http://www.ncbi.nlm.nih.gov/ - Daidzein

http://extension.agron.iastate.edu/
What are soy isoflavones? Isoflavones are biologically-active, nonnutritive compounds that are present in relatively large amounts in soybean and soyfoods. Soybeas contain two main types of isoflavones; daidzein and genistein. These compounds are part of a larger group of plant chemicals, called flavenoids, that are common in many fruits, vegetables, and legumes. Soybean are by far the most concentrated source of isoflavones in the human diet. Isoflavones are produced by the soybean plant as part of their defense mechanism against insects and diseases such as Phytophthora, and in response to environmental stresses such as drought. Isoflavones also play an important role in the growing soybean plant by stimulating nodule formation by nitrogen-fixing Rhizobium bacteria.

Local:
Daidzein is the genin of daidzin. They are abundant in soybeans. Daidzein is a phytoestrogen suggested to play a role in preventing hormone-induced cancers. Daidzein inhibits metabolic activation of benzo[a]pyrene and hydrogen peroxide production in 12-O-tetradecanoylphorbol-13-acetate. It is known to be useful to treat hypertension and menopausal syndrome as well as alcoholism. Daidzein is a white crystalline powder; insoluble in water and chlorform, slightly solube in alcohol. Chemical designation is 7-hydroxy-3- (4-hydroxyphenyl)-4H -1-benzopyran-4-one.

GENERAL DESCRIPTION OF FLAVONOID: Flavonoid is any member of a class of widely distributed biological natural products containing aromatic heterocyclic skeleton of flavan (2-Phenylbenzopyran) but no nitrogen in plants. Generally, flavonoids are biological pigments providing colours from red to blue in flowers, fruit and leaves. Besides their coloring in plants, flavonoids have important roles in the growth and development of plants; protection against UV-B radiation; forming antifungal barriers; antimicrobial, insecticidal and oestrogenic activities; plant reproduction. Flavonoids also exhibit a wide range of biological properties including anti-microbial, insecticidal and oestrogenic activities. Flavonoids are usually classified into main 6 subgroups as below plus flavans, neoflavonoids, flavonols, aurons, catechins according to the structural patterns.

  • Flavonols (Hydroxy derivatives of flavone): Fisetin, Galangin, Kaempferide, Kaempferol, Morin, Myricetin, Myricitrin, Quercetin, Quercetrin, Rhamnetin, Robinin, Rutin, Spirenoside
  • Flavones (skeleton: 2-phenylchromen-4-one): Apigenin, Baicalein, Chrysin, Diosmetin, Diosmin, Flavone, Luteolin, Rpoifolin,Tangeretin, Techtochrysin, Rhamnazin, Nobiletin, Natsudaidain.
  • Isoflavones (skeleton: 3-phenylchromen-4-one): Daidzin, Genistein, Irilone, Luteone, Prunetin, Pratensein,
  • Flavonones (derivation by reduction of the 2(3) C=C bond): Eriodictyol, Hesperidin, Hesperetin, Likvirtin, Naringin; Naringenin; Pinocembrin
  • Flavanols (derivation by reduction of the keto group):(+)-Catechin, (+)-Gallocatechin, (-)-Epicatechin (EC), (-)-Epigallocatechin (EGC), (-)-Epicatechin 3-gallate (ECG), (-)-Epigallocatechin 3-gallate (EGCG), Theaflavin, Theaflavin 3-gallate, Theaflavin 3'-gallate, Theaflavin 3,3' digallate, Thearubigins
  • Anthocyanidins (aglycones of the glycoside anthocyanins): Apigeninidin, Cyanidin, Delphinidin, Diosmetinidin, Guibourtinidin, Fisetinidin, Luteolinidin, Malvidin, Pelargonidin, Peonidin, Robinetinidin, Tricetinidin, Capensinidin, Petunidin, Europinidin, Aurentinidin, Columnidin, 5-Desoxy-malvidin, 5-Desoxy-peonidin, Hirsutinidin, Rosinidin
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

ASSAY

98.0% min

TOTAL IMPURITY

2.0% max

LOSS ON DRYING

1.0% max

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

May cause respiratory tract irritation. Causes eye and skin irritation. Target Organs: Eyes, skin.

GHS

 

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H315-H319

P STATEMENTS

P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

RIS PHRASES

36/38

SAFETY PHRASES

24-26